Comparison of I-124 PET/CT for the Diagnosis of Thyroid Cancer

Launched by THOMAS HOPE · Apr 29, 2025

Keywords

ClinConnect Summary

This clinical trial is studying a new imaging method using Iodine-124 (I-124) to detect metastatic thyroid cancer, which means cancer that has spread from the thyroid to other parts of the body. Currently, doctors use other types of imaging, like Iodine-123 (I-123) and Iodine-131 (I-131), to help find and monitor thyroid cancer. The goal of the trial is to see if I-124 can provide better or more accurate information about the cancer compared to these traditional methods.

To participate in this trial, you need to be at least 18 years old and have been diagnosed with a specific type of thyroid cancer that doctors suspect might have spread. This suspicion can come from previous imaging tests or high levels of a protein called thyroglobulin in your blood after surgery to remove the thyroid. If you decide to join, you'll have a standard imaging test with I-123 within 45 days after enrolling. It's important to understand the study procedures and agree to participate by signing a consent form. This study is not yet recruiting participants, so it's a good idea to check back later if you're interested.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. Age \>= 18 years.
• 2. Histopathologically confirmed differentiated thyroid cancer, with clinical concern for metastatic disease, which is based on:
• • 1. Metastatic disease seen on I-123 SPECT, Fluorodeoxyglucose (FDG) PET, CT scan or ultrasound.
• • 2. Elevated thyroglobulin in participant after total thyroidectomy.
• • i. Participants with an undetectable thyroglobulin will be allowed if thyroglobulin antibodies are present.
• • 3. Planned I-123 imaging within 45 days after enrollment.
• • 4. Ability to understand a written informed consent document, and the willingness to sign it.
• Exclusion Criteria:
• • 1. Unlikely to comply with study procedures, restrictions and requirements and judged by the Investigator to be unsuitable for participation.
• • 2. Known pregnancy, per institutional policy.