Linked-Color Imaging Versus Indigo Carmine Pump Spraying on the Colorectal Adenoma Detection Rate

Launched by SHANDONG UNIVERSITY · May 5, 2025

Keywords

ClinConnect Summary

This clinical trial is studying two different methods to help doctors find and remove polyps in the colon during a procedure called a colonoscopy, which is important for preventing colorectal cancer. One method is called linked-color imaging (LCI), a newer technology that uses special camera techniques to make polyps easier to see. The other method is indigo carmine spraying, which involves using a blue dye to highlight the polyps. Researchers are comparing how effective these two methods are at detecting adenomas, a type of polyp that can lead to cancer.

To be eligible for this study, participants need to be between 45 and 85 years old and have a history of colorectal adenomas or related family history, gastrointestinal symptoms, or a positive stool test for blood. However, certain individuals, such as those with inflammatory bowel disease or recent use of blood thinners, cannot participate. Those who join the trial can expect to undergo a colonoscopy where their doctor will use either LCI or indigo carmine to check for polyps. This research aims to find out which method is better at detecting polyps, ultimately helping to improve cancer prevention efforts.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. Age between 45 and 85 years
• • 2. Patients with a history of colorectal adenoma
• • 3. Patients whose first-degree relatives have a history of colorectal cancer or colorectal adenoma
• • 4. Patients with gastrointestinal symptoms (abdominal pain, bloody stool, chronic diarrhea or constipation, Unexplained anemia or weight loss;
• • 5. Patients with positive Fecal Immunochemical Test
• Exclusion Criteria:
• • 1. Patients with pregnancy, inflammatory bowel disease, familial adenomatosis polyposis, suspected CRC; intestinal obstruction, coagulopathy
• • 2. Patients with aspirin, clopidogrel or other anticoagulants/ antiplatelet drugs intake within 7 days
• • 3. Patents previous colorectal resection
• • 4. Patients with failed cecal intubation
• • 5. Patients with inadequate bowel preparation quality (BBPS≤5)
• • 6. Patients who refuse to participate or to provide informed consent