Observational Study of Platelet Dysfunction Assessed by Thromboelastography in Cardiovascular Surgery (DISPLATEG)

Launched by FUNDACIÓN INSTITUTO DE ESTUDIOS DE CIENCIAS DE LA SALUD DE CASTILLA Y LEÓN · Apr 29, 2025

Keywords

ClinConnect Summary

The DISPLATEG study is looking at how well platelets, which are important for blood clotting, work in patients undergoing heart surgery. Sometimes, patients can experience bleeding during or after surgery, especially if they are on a heart-lung machine (called cardiopulmonary bypass). This study aims to find out if patients who have lower activity in their platelets, specifically related to a substance called ADP, are more likely to experience significant bleeding after surgery.

To be part of this study, participants need to be at least 18 years old and scheduled for elective heart surgery that requires the heart-lung machine. They should not have taken certain blood-thinning medications recently, and their blood tests should show normal platelet levels. Those who join the study will help researchers understand the relationship between platelet function and bleeding, which could lead to improved care for patients undergoing similar surgeries in the future. The study is not yet recruiting participants, but it’s an important step towards better understanding and preventing complications in heart surgery.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Over 18 years of age.
• • Patients undergoing elective surgery under CPB.
• • Patients must be duly informed and have signed the informed consent form.
• • ASA status I-IV.
• • Sufficient intellectual capacity to understand the procedure.
• • Normal preoperative coagulation study and platelet count.
• Exclusion Criteria:
• • Failure to meet the criteria listed above.
• • Preoperative administration of antiplatelet agents with an inadequate washout period (5 days for clopidogrel and ticagrelor and 7 days for plasugrel).
• • Preoperative administration of anticoagulants with an inadequate washout period.
• • Thrombopenia \<100,000 platelets or anemia \<11 g/dL