Effectiveness of Ventilation Modes in Intensive Care: A Comparison of Mandatory Minute Ventilation and Synchronized Intermittant Mandatory Ventilation Using Bioelectrical Impedance Tomography

Launched by HARRAN UNIVERSITY · Apr 29, 2025

Keywords

ClinConnect Summary

This clinical trial is comparing two different ways of helping patients breathe in the intensive care unit (ICU): Synchronized Intermittent Mandatory Ventilation (SIMV) and Mandatory Minute Ventilation (MMV). SIMV is a common method that helps patients breathe by delivering air at a set rhythm while also allowing them to breathe on their own. MMV, on the other hand, ensures patients get a specific amount of air over time, even if they are not breathing deeply enough on their own. The study will monitor how well each method works using a special imaging technique called Electrical Impedance Tomography (EIT), which safely checks how well air is moving in and out of the lungs.

To be eligible for this trial, participants need to be at least 18 years old and currently on a ventilator in the ICU, but they should be stable enough not to need certain medications that support blood pressure. They must also have specific limits on the amount of oxygen and pressure used in their ventilation. If enrolled, patients will experience both breathing methods, with a short break in between to ensure accurate results. This study is important as it aims to find out which ventilation method is more effective for patients in critical care, potentially improving their recovery process.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Age ≥ 18 years
• • Intubated and receiving invasive mechanical ventilation
• • Hemodynamically stable (no vasopressor support)
• • FiO₂ ≤ 60%
• • PEEP ≤ 8 cmH₂O
• • Not receiving neuromuscular blocking agents
• • Able to tolerate switching between SIMV and MMV modes
• Exclusion Criteria:
• • Pregnant or breastfeeding patients
• • Patients with neuromuscular diseases affecting respiratory drive
• • Unstable hemodynamics or ongoing need for vasopressors
• • Patients requiring high PEEP (\>8 cmH₂O)
• • Patients with DNR (do not resuscitate) status
• • Participation in another interventional study
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