Assessment of Salivary GM-CSF, MIP, and IL-1β Levels in Subjects With Varying Periodontal Conditions

Launched by IZMIR KATIP CELEBI UNIVERSITY · Apr 29, 2025

Keywords

ClinConnect Summary

This clinical trial is studying the levels of certain proteins in saliva that may help understand different gum diseases, like gingivitis (inflammation of the gums) and periodontitis (a more severe form of gum disease). The researchers want to see if these proteins, known as GM-CSF, MIP-1α, and IL-1β, can be used to tell the difference between healthy gums and those with disease. They will collect saliva samples from 60 healthy individuals, as well as those with gingivitis and periodontitis, to compare the levels of these proteins and see if they relate to the severity of gum disease.

To participate in this study, individuals must be generally healthy, have at least 20 permanent teeth, and should not be smokers or taking medications regularly. They should also not be pregnant or breastfeeding. Participants will undergo routine dental checks, and their saliva will be tested for the proteins mentioned above. This research could lead to new ways to diagnose gum diseases and create better treatment plans in the future.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Systemically healthy participants.
• • At least twenty permanent teeth present in the oral cavity.
• • Non-smokers.
• • No medication for continuous use.
• • Not pregnant or breastfeeding.
• Exclusion Criteria:
• • Any oral or systemic disease.
• • Regular use of systemic medications.
• • Pregnancy or lactation.
• • Received periodontal treatment within the last 6 months.
• • Use of antibiotics, anti-inflammatory medications, or systemic corticosteroids in the last 6 months.
• • Smokers.