End-tidal Carbon Dioxide as a Non-invasive Predictor for Changes in Cardiac Output in Non-cardiac Surgery
Launched by AIN SHAMS UNIVERSITY · May 7, 2025
Trial Information
Current as of July 09, 2025
Not yet recruiting
Keywords
ClinConnect Summary
This clinical trial is investigating whether measuring carbon dioxide levels in a patient's breath can help predict changes in blood flow from the heart during non-cardiac surgeries. This is important because knowing how well the heart is pumping blood can be difficult to measure without invasive procedures that can carry risks. The researchers believe that brain blood flow is linked to overall heart output, so they are exploring if checking carbon dioxide levels could provide a safer way to gauge heart performance during surgery.
To be eligible for this study, participants need to be between 18 and 55 years old and in good health (specifically classified as ASA physical status I-II) undergoing certain types of surgeries that do not involve the head and neck, or orthopedic surgeries of the lower limbs. Participants will not be able to join if they have specific health issues like respiratory diseases or significant obesity. Those who join the study can expect to have their carbon dioxide levels measured during surgery to see if it can effectively indicate heart function without the need for more invasive methods. This study is currently not recruiting participants, but it aims to improve patient safety and monitoring during surgery.
Gender
ALL
Eligibility criteria
- Inclusion Criteria:
- • The patients age will be ranged from 18-55 years,
- • ASA physical status I-II,
- • General surgeries not involving the head and neck
- • Orthopedic surgeries involving the lower limb
- • Patients in supine posture
- Exclusion Criteria:
- • Those with Respiratory disease including but not limited to Pneumonia, COPD, Restrictive lung disease and ARDS
- • Those with anemia.
- • Patients' refusal to participate in the study.
- • Thoracic surgeries.
- • Morbidly obese patients.
- • Significant carotid artery disease.
- • Surgeries of less than 2-hour duration.
About Ain Shams University
Ain Shams University, established in Cairo, Egypt, is a prestigious higher education institution renowned for its commitment to academic excellence and research innovation. As a clinical trial sponsor, the university leverages its extensive resources and expertise in various medical and scientific disciplines to advance healthcare through rigorous research initiatives. With a focus on ethical practices and adherence to regulatory standards, Ain Shams University aims to contribute to the development of new therapies and improve patient outcomes, fostering collaboration among researchers, healthcare professionals, and industry partners in the pursuit of medical advancements.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Cairo, Abbassia, Egypt
Patients applied
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported