Interventions for Weight Regain After Bariatric Surgery

Launched by MEDIPOL UNIVERSITY · May 6, 2025

Keywords

ClinConnect Summary

This clinical trial is studying different ways to help people who have had weight loss surgery but are struggling with not losing enough weight or gaining some of it back. The three approaches being tested are revisional bariatric surgery (a follow-up surgery), a very low-calorie ketogenic diet (a specific eating plan that is low in carbohydrates), and intermittent fasting (a diet that alternates between eating and not eating). The goal is to see how these methods affect patients' eating habits and health outcomes, such as weight and blood tests, and compare the results with a control group that does not receive these interventions.

To participate, individuals need to be between 18 and 45 years old and have had weight loss surgery within the last 18 months. They should be experiencing either inadequate weight loss (not losing enough weight compared to what is expected) or weight regain (gaining back a significant amount of the weight they lost). It’s important to note that pregnant women, those with certain health conditions, or professional athletes are not eligible to join this study. Participants can expect to receive one of the three treatments and will be monitored closely to understand how well each method works.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Patients aged between 18 and 45 years who have undergone bariatric surgery (BS).
• • Experiencing inadequate weight loss (IWL) within 18 months after surgery or weight regain (WR) following successful weight loss.
• * Definitions used in the study:
• • IWL is defined as \<50% excess weight loss (EWL) 18 months postoperatively. WR is defined as \>25% regain of the lost weight (from the lowest achieved weight).
• • -
• Exclusion Criteria:
• • Pregnant or lactating women.
• • Patients with acute illnesses, infections, or comorbidities that may affect treatment efficacy or safety (e.g., cancer, type 1 diabetes, renal or hepatic failure, recent stroke or myocardial infarction, nephrolithiasis, substance or alcohol abuse, eating disorders, severe depression or other psychiatric disorders, inflammatory bowel disease, neoplasms, arrhythmic heart diseases, heart failure, respiratory failure).
• • Patients currently receiving corticosteroid therapy.
• • Professional athletes.