The Effect of Vitamin D Supplement as Adjuvant Therapy in Eradication of Helicobacter Pylori Infection

Launched by ASSIUT UNIVERSITY · May 1, 2025

Keywords

ClinConnect Summary

This clinical trial is studying whether taking vitamin D can help improve the treatment of Helicobacter pylori (H. pylori) infection, which is a common bacterial infection that can cause stomach problems like gastritis and ulcers. Researchers believe that vitamin D might help the body fight this infection better by boosting the immune system. The trial is looking for children between the ages of 1 and 16 who have been diagnosed with H. pylori infection and are experiencing symptoms like weight loss or abdominal pain.

If your child is eligible and participates in the trial, they will receive treatment that includes vitamin D along with standard medications to help clear the infection. The trial aims to determine if adding vitamin D to the usual treatment can enhance the effectiveness of the therapy. It’s important to note that certain health conditions or previous treatments may exclude a child from participating. This study has not started recruiting participants yet, but it offers hope for better treatment options for those affected by H. pylori infections.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Patients aged between 1 to 16 years old who present with helicobacter pylori infection diagnosed by positive stool antigen test for helicobacter pylori infection presented with weight loss, abdominal pain, or failure to surive symptoms for at least 1 month.
• Exclusion Criteria:
• • - 1. Known hypersensitivity to PPIS or antibiotics. 2. Patients who have previously received helicobacter pylori eradication treatment, corticosteroids/immunosuppressive treatment and acid suppressive treatment in the prior 2 months.
• • 3. History of systemic inflammatory or autoimmune disorders, gastric surgery, renal failure, liver cirrhosis and malignancies 4. Abnormal birth history such as premature birth and asphyxia or with severe disease history, such as genetic metabolic disease, congenital dysplasia, feeding difficulties, severe malnutrition, repeated respiratory diseases.