Cognitive Rehabilitation of Deficits in Patients With Multiple Sclerosis

Launched by UNIVERSITA DI VERONA · Apr 30, 2025

Keywords

ClinConnect Summary

This clinical trial is exploring a new way to help people with Multiple Sclerosis (MS) improve their thinking and memory skills through a computer-based treatment delivered online, called telerehabilitation. The main goal is to find out if this online approach works just as well as traditional in-person therapy for helping with attention and other cognitive tasks. In addition, the study will also look at how telerehabilitation affects other areas like memory, executive functions (which help with planning and problem-solving), daily activities, and overall well-being, including mood and quality of life.

To participate in the trial, individuals need to be between 18 and 65 years old and have a diagnosis of MS that has lasted for at least 3 to 6 months. They should also have mild to moderate disability and experience cognitive issues like memory or attention difficulties. Participants must have internet access at home and be able to see and hear well enough to use the rehabilitation device. Those with other neurological or psychiatric conditions, or severe visual problems, will not be eligible. If you join the study, you’ll receive either the online treatment or the in-person therapy, and researchers will monitor your progress to understand how well each method works.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Diagnosis of relapsing-remitting multiple sclerosis (RRMS), or primary progressive (PPMS) or secondary progressive (SPMS), defined by at least 3-6 months.
• • Age between 18 and 65 years.
• • Expanded Disability Status Scale (EDSS) between 3 and 5 to include patients with overall neurological disability from mild to moderate.
• * Presence of one or more of the following cognitive disorders (reported by the patient and subsequently confirmed through the Oxford Cognitive Screen-OCS):
• • Memory disorders
• • Attention disorders
• • Executive function disorders
• • Availability of internet at the patient's home necessary for the tele-rehabilitation procedures.
• • Adequate visual and auditory abilities to use the rehabilitation device.
• Exclusion Criteria:
• • Presence of other neurological conditions;
• • Psychiatric disorders in medical history;
• • Alcohol and/or drug abuse;
• • Presence of uncorrected severe visual deficits.