Research on Probiotics in Improving Obesity

Launched by WECARE PROBIOTICS CO., LTD. · May 7, 2025

Keywords

ClinConnect Summary

This clinical trial is exploring the effects of a specific type of probiotic, called Akkermansia muciniphila Akk11, on improving obesity in adults. Probiotics are live bacteria that are good for our health, and in this study, researchers want to see if taking capsules of heat-killed Akkermansia can help reduce body weight, body fat, and improve cholesterol levels compared to a placebo (a capsule with no active ingredients). They are looking for overweight or obese adults aged 18 to 65 who have a Body Mass Index (BMI) of 25 or higher and are willing to follow a low-carbohydrate diet during the trial.

If you decide to participate, you will need to commit to the study's guidelines, including dietary restrictions, and you’ll need to provide consent to take part. Unfortunately, some people may not be eligible, such as those with certain health conditions, those who are pregnant or breastfeeding, or those who have used similar products recently. Participants can expect to take the probiotic capsules and attend follow-up appointments to monitor their progress. This trial is currently recruiting, so it’s a good opportunity for those looking to improve their health through dietary changes and probiotic use.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. A body mass index (BMI) of ≥25 kg/m²;
• • 2. Willingness to provide written informed consent to participate in the study;
• • 3. Agreement to adhere to the study protocol and restrictions, including a low-carbohydrate, energy-restricted diet;
• • 4. No plans for conception from 14 days before screening until 6 months after the trial, with a commitment to using effective contraception.
• Exclusion Criteria:
• • 1. Use of products similar to the test product in the near term that may affect the results;
• • 2. Presence of mental or neurological disorders, celiac disease, lactose intolerance, or allergies;
• • 3. Pregnant, breastfeeding, or planning pregnancy;
• • 4. Irritable Bowel Syndrome (IBS), Ulcerative Colitis, Hepatic Cirrhosis, or Diabetes Mellitus;
• • 5. Antibiotic use within the past three months;
• • 6. Failure to consume the test product as required or attend follow-ups on time, making efficacy assessment impossible;
• • 7. Smoking more than 10 cigarettes a day;
• • 8. Allergy to probiotic products;
• • 9. Other participants deemed unsuitable for the study by the investigator.