Microplastics and Nanoplastics (MNPs) in Patients With ST-elevation Myocardial Infarction (STEMI)

Launched by AZIENDA OSPEDALIERA "SANT'ANDREA" · May 1, 2025

Keywords

ClinConnect Summary

This clinical trial is studying the effects of microplastics and nanoplastics, tiny plastic particles found in our environment, on patients who have experienced a severe heart attack known as ST-elevation myocardial infarction (STEMI). Researchers want to understand if these particles are present in blood clots that form during the heart attack and if they contribute to further heart damage or complications. To do this, they will use special imaging techniques to look at heart health and track patients for one year to see if there are more heart-related issues in those with higher amounts of these pollutants.

To be eligible for the trial, participants must be over 18 years old and have had a STEMI that requires immediate treatment. They should also be able to provide consent to participate. However, those with certain health conditions, such as severe kidney disease or serious heart instability, cannot join the study. If you take part in this trial, you will help researchers learn more about the potential impact of plastic pollution on heart health, which could lead to better treatments and outcomes for heart attack patients in the future.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• All the following inclusion criteria should be fulfilled:
• • 1. Age \> 18 years old;
• • 2. STEMI undergoing urgent invasive coronary angiography;
• • 3. Acute thrombotic coronary occlusion/sub-occlusion (TIMI 0/1);
• • 4. Clinical indication to thromboaspiration;
• • 5. Able to give informed consent.
• Exclusion Criteria:
• • 1. Contraindications to percutaneous coronary intervention;
• • 2. Hemodynamic instability or cardiogenic shock;
• • 3. End-stage chronic kidney disease;
• • 4. Life expectancy \< 1 year due to non-cardiac pathology.