Multiprofen-CC to Reduce Pain in Hand Arthritis

Launched by MCMASTER UNIVERSITY · May 2, 2025

Keywords

ClinConnect Summary

This clinical trial is studying a cream called Multiprofen-CC to see if it can help reduce pain in adults with hand osteoarthritis, a condition that causes pain and stiffness in the hands. Participants will apply the cream to their hands three times a day for four weeks, and some will use a placebo cream that has no active ingredients, so neither the participants nor the researchers will know who is using which cream at first. The study will also look at how well the cream works for improving hand function, reducing the need for pain medications, and how patients feel about their overall improvement.

To be eligible for this study, participants need to be at least 18 years old and diagnosed with hand osteoarthritis that causes pain or affects their daily activities. They should also be willing to follow the study instructions and attend visits at the beginning, after two weeks, and after six weeks. However, people with certain conditions, like severe skin issues on their hands, recent hand surgery, or those who regularly take strong pain medications, won't be able to join the trial. Participants will keep track of any symptoms or side effects they experience during the study.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Adults (18+)
• • Have been diagnosed with hand osteoarthritis according to American College of Rheumatology criteria
• • Experience pain and/or loss of function in one or both hands that interferes with daily life
• • Provide informed consent
• Exclusion Criteria:
• • Unable to consent
• • Unable or unwilling to follow study protocol
• • Known allergy or contraindication to any of the study drugs or their ingredients
• • Have open wounds/cuts and/or skin conditions on the hand area
• • Pregnant or breastfeeding
• • History of impaired kidney or liver function
• • Rheumatoid or other inflammatory arthropathy
• • Hand surgery within the past 6 months or planned within the study period.
• • Use daily opioids (other than short acting codeine) for a chronic pain condition other than hand arthritis