IEEM- Work:Rest Cycles in Burn Survivors- Humidity

Launched by UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER · May 2, 2025

Keywords

ClinConnect Summary

This clinical trial, titled "IEEM- Work:Rest Cycles in Burn Survivors- Humidity," aims to understand how severe burn injuries affect the body's ability to manage temperature during activities in hot environments. The researchers want to learn how different levels of burn injuries—mild to severe—impact the body’s response to heat and how often people need to rest while working in such conditions.

To participate, individuals must be between 18 and 65 years old and in good overall health, meaning they shouldn't have serious medical issues like heart disease or diabetes. Those who have experienced burns covering 20% to over 40% of their body are eligible, but they must also meet specific health criteria. Participants will engage in exercises while the researchers monitor their temperature responses, helping to improve care for burn survivors in future situations. If you're interested in this study, it’s important to know that it’s not yet open for recruitment, but keep an eye out for updates!

Gender

ALL

Eligibility criteria

• Inclusion Criteria for Non-burned Individuals:
• • Participants must be free of any significant underlying medical problems based upon a detailed medical history and physical exam, and normal resting electrocardiogram. Participants must be between the ages of 18 and 65.
• Exclusion Criteria for Non-burned Individuals:
• • Known heart disease; other chronic medical conditions requiring regular medical therapy including cancer, diabetes, neurological diseases, and uncontrolled hypertension, lung disease, etc.; as well as serious abnormalities detected on routine screening. Current smokers, as well as individuals who regularly smoked within the past 3 years will be excluded. Participants may also be excluded if body mass index is ≥ 31 kg/m2 will likewise be excluded. Participants must not have had a serious burn injury requiring more than 1 night stay in the hospital.
• Inclusion Criteria for Individuals with up to 40% of their body surface area burned (moderate burn group):
• • - Participants must be free of any significant underlying medical problems based upon a detailed medical history and physical exam, and normal resting electrocardiogram. Participants who have sustained a burn injury must have a burn covering 20-40% of their body surface area and 50% of those burns must be full-thickness burns requiring skin grafts. Participants must be between the ages of 18 and 65.
• Exclusion Criteria for Individuals with up to 40% of their body surface area burned (moderate burn group):
• • - Known heart disease; other chronic medical conditions requiring regular medical therapy including cancer, diabetes, neurological diseases, and uncontrolled hypertension, lung disease, etc.; as well as serious abnormalities detected on routine screening. Current smokers, as well as individuals who regularly smoked within the past 3 years will be excluded. Participants may also be excluded if body mass index is ≥ 31 kg/m2 will likewise be excluded.
• Inclusion Criteria for Individuals with greater than 40% of their body surface area burned (large burn group):
• • - Participants must be free of any significant underlying medical problems based upon a detailed medical history and physical exam, and normal resting electrocardiogram. Participants who have sustained a burn injury must have a burn covering more than 40% of their body surface area and 50% of those burns must be full-thickness burns requiring skin grafts. Participants must be between the ages of 18 and 65.
• Exclusion Criteria for Individuals with greater than 40% of their body surface area burned (large burn group):
• • - Known heart disease; other chronic medical conditions requiring regular medical therapy including cancer, diabetes, neurological diseases, and uncontrolled hypertension, lung disease, etc.; as well as serious abnormalities detected on routine screening. Current smokers, as well as individuals who regularly smoked within the past 3 years will be excluded. Participants may also be excluded if body mass index is ≥ 31 kg/m2 will likewise be excluded.