Quantifying Ocular Surface Aberrations After Tear Film Interventions

Launched by UNIVERSITY OF WATERLOO · May 2, 2025

Keywords

ClinConnect Summary

This clinical trial, titled "Quantifying Ocular Surface Aberrations After Tear Film Interventions," is looking to understand how different treatments, like eye drops and contact lenses, affect the tear film on the surface of the eye. Researchers will use a special device called the CA-800 Corneal Analyzer to measure tiny imperfections in the tear film when your eyes are open. The goal is to see if these treatments cause any noticeable changes in the tear film, which is important for eye health and comfort.

To participate in this study, you need to be at least 17 years old, willing to follow study instructions, and regularly wear soft contact lenses (not multifocal or toric lenses) for at least six hours. You should also have good vision and no recent history of eye problems. If you qualify, you'll be asked to wear specific study contact lenses while your tear film is measured. Importantly, this study is not yet recruiting participants, but it’s a great opportunity for those who meet the criteria to contribute to understanding eye care better.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. Are at least 17 years of age and have full legal capacity to volunteer.
• • 2. Have signed the information consent letter.
• • 3. Are willing and able to follow instructions and maintain the appointment schedule.
• • 4. Habitually wear spherical soft contact lenses (no multifocal lens, no toric lens wear or extended (overnight) wear).
• • 5. Have a vertex-corrected refractive astigmatism of no more than 0.75D in each eye.
• • 6. Achieve a best corrected visual acuity of 0.00 logMAR or better in each eye.
• • 7. Agree to wear the study contact lenses for at least 6 hours.
• • 8. Have clear corneas (e.g. no central scars).
• • 9. Have no active ocular disease or inflammation.
• Exclusion Criteria:
• • 1. Are participating in another concurrent clinical research study.
• • 2. Have worn any rigid contact lenses in the past 30 days.
• • 3. Have been diagnosed with irregular cornea (e.g., keratoconus, etc.).
• • 4. Have any known active ocular condition, disease, and/or infection.\*
• • 5. Have a systemic or ocular condition that, in the opinion of the investigator, may affect a study outcome variable.
• • 6. Have a known sensitivity to the diagnostic sodium fluorescein to be used in the study.
• • 7. Have undergone refractive error surgery.
• • 8. Are a member of the study team for this study, i.e. are listed on the delegation log for this study.