Prone Positioning in ARDS: Predicting Neurological Complications Via Cerebral Hemodynamics

Launched by SICHUAN PROVINCIAL PEOPLE'S HOSPITAL · May 3, 2025

Keywords

ClinConnect Summary

This clinical trial is looking at how a specific treatment called "prone positioning" might help patients with moderate to severe Acute Respiratory Distress Syndrome (ARDS), a serious lung condition. The study aims to understand if this method, where patients lie on their stomachs, has any effects on brain blood flow and whether it could lead to neurological complications. Researchers are currently recruiting participants aged 18 and older who meet certain health criteria, such as needing mechanical ventilation for more than 48 hours due to ARDS.

If you or a family member are considering participating, you should know that participants will need to provide written consent and will be closely monitored during the study. However, there are specific exclusions; for example, individuals with certain head and neck injuries, severe neurological diseases, or life-threatening ARDS cannot join. Overall, this trial hopes to gather important information that could improve care for patients with ARDS.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Age≥18 years
• • Meet the diagnostic criteria for ARDS(Acute Respiratory Distress Syndrome),with PaO₂/FiO₂\<150 mmHg,and requiring prone ventilation
• • Expected duration of mechanical ventilation\>48 hours
• • Written informed consent obtained
• Exclusion Criteria:
• • Presence of contraindications to prone positioning(e.g.,head and neck injuries,spinal instability,severe intracranial hypertension)
• • Severe neurological diseases(e.g.,cerebral hemorrhage,cerebral infarction,intracranial space-occupying lesions)that may affect the monitoring of cerebral hemodynamics
• • Life-threatening ARDS
• • Patients who are unable to undergo neurological assessment
• • Poor image quality or absence of images