Multimodal Imaging and Biospecimen Collection for Low Back Pain (LBPB)

Launched by PEKING UNIVERSITY THIRD HOSPITAL · May 2, 2025

Keywords

ClinConnect Summary

This clinical trial is looking at the complex reasons behind low back pain, which can be either short-term (acute) or long-term (chronic). Researchers want to understand how factors like genetics, emotions, sleep, and other health conditions affect pain. They will collect samples and data from participants to help identify different types of low back pain and their underlying causes. The ultimate goal is to develop better ways to predict how pain progresses and to create personalized treatments that work for different individuals.

To participate, you need to be an adult aged 18 to 80 who has been diagnosed with low back pain. You should be open to various treatment options and willing to undergo some tests, like brain scans and psychological assessments. However, those with severe neurological issues, certain digestive diseases, or who have had specific recent medical treatments may not qualify. Participants can expect to contribute to important research that could lead to better pain management strategies in the future.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. Adults aged 18 to 80 years.
• • 2. Diagnosis of low back pain, defined as pain located between the lower costal margins and the gluteal folds, with or without leg pain.
• • 3. Eligible for surgical or non-surgical treatments.
• • 4. Willingness to undergo neuroimaging (fMRI), microbiota sampling, psychological assessments, and other related study procedures. Ability to provide written informed consent.
• Exclusion Criteria:
• • 1. Severe neurological deficits requiring emergency surgery.
• • 2. Antibiotic or probiotic use within the past 4 weeks. Suffering from digestive diseases such as irritable bowel syndrome, gastric ulcer, duodenal ulcer, etc.;
• • 3. Diagnosed spinal infections, tumors, fractures, or inflammatory diseases (e.g., ankylosing spondylitis).
• • 4. Known severe psychiatric disorders (e.g., schizophrenia, bipolar disorder) that would interfere with study participation.Head trauma; history of substance abuse.
• • 5. Contraindications to MRI scanning (e.g., pacemaker, metallic implants, severe claustrophobia).
• • 6. Pregnant or breastfeeding women.
• • 7. Participation in another interventional clinical trial within the past 3 months.
• • 8. Working at night shifts or travelling across time zones in the past 6 months.
• • 9. Excessive consumption of coffee, tea.