Comparative Effects of Two Oral Antiseptics Used as an Adjuvant in the Treatment of Periodontitis

Launched by THE UNIVERSITY OF HONG KONG · May 12, 2025

Keywords

ClinConnect Summary

This clinical trial is studying two different mouthwashes used to help treat gum disease, specifically periodontitis. One mouthwash contains a higher concentration of chlorhexidine (0.2%), while the other has a lower concentration (0.12%) combined with another ingredient called cetylpyridinium chloride (CPC). Researchers want to see if the lower concentration mouthwash is just as effective at reducing plaque and gum inflammation but results in fewer side effects, like changes in taste or mouth irritation. To do this, they will collect samples from participants' mouths before and after using the mouthwash for 21 days.

To participate in this trial, you must be between 65 and 74 years old, have generalized stage II or III periodontitis, and have at least six teeth that can be evaluated. You should not smoke or have certain medical conditions, and you should not have taken specific medications or treatments in the last three months. If you qualify and choose to join, you will use one of the mouthwashes as directed and attend follow-up appointments for evaluations. This study aims to find a more comfortable treatment option while still effectively managing gum disease.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Consenting patients with at least 6 evaluable teeth in each quadrant, including minimum 1 molar and 1 premolar.
• • Generalized stage II-III periodontitis patients.
• • Baseline BOP \> 25%.
• • No known allergy or adverse effects to CHX or CPC
• • Non-smokers, non-orthodontic patients, no concurrent or past antibiotics/medication known to affect periodontal status (i.e. calcium antagonists, phenytoin)/anti-inflammatory therapy (i.e. NASIDs) in the last 3 months, pregnant/breastfeeding, compliance to study procedures.
• • ASA class I-II patients.
• • Either non-diabetic or with controlled diabetes (HbA1C\<7).
• • Normal/Elevated blood pressure (AHA - Systolic \<130mmHg; Diastolic \<80mmHg).
• • No radiation/chemotherapy in the past 5 years
• • No immunosuppression including drug induced immunosuppression.
• • No participation in other clinical studies in the last 4 weeks.
• • No administration of CHX or CPC in the last 3 months
• • No periodontal treatment in the last 3 months.
• Exclusion Criteria:
• • Unable to provide written consent.
• • Non-compliant study procedures.
• • Patients with medical (including psychiatric) and pharmacotherapeutic histories that, in the investigator's opinion, may compromise the protocol.
• • Patients requiring antibiotics prophylaxis for dental procedures.
• • Patients with self-reported pregnancy or patients who are breastfeeding.
• • Patients with history of use of systemic antibiotics, in combination with any form of periodontal treatment, within the past 3 months.
• • Patients with uncontrolled endocrine disease.
• • Patients who are not compliant with the review protocol, leading to deviation of more than 1 week.
• • Patients requiring the admission of systemic antibiotics, in combination with any form of dental treatment, during the study period.