Perfusion Index in Pediatric Low-Flow Anesthesia

Launched by ISTINYE UNIVERSITY · May 3, 2025

Keywords

ClinConnect Summary

This clinical trial is looking at how a measure called the perfusion index (PI) changes in children during surgery when they receive low-flow anesthesia, which uses less gas than normal. The study will track the PI at different times during and after surgery to see how it relates to how stable the child's blood flow is and how deeply they're under anesthesia. Researchers also want to find out if using low-flow anesthesia affects the chances of children experiencing emergence agitation, which is when they may feel confused or restless as they wake up from anesthesia.

To participate, children aged 2 to 12 who are healthy and scheduled for elective surgeries lasting between 1 to 6 hours may be eligible. However, those with certain health conditions or who are undergoing emergency surgeries will not be included. Families can expect that their child will receive standard care during the trial, and no extra treatments will be given beyond what is normally done in these situations. This study aims to help improve safety and recovery for children undergoing anesthesia in the future.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • ASA I-II pediatric patients
• • Age 2 to 12 years
• • Undergoing elective surgery lasting between 1-6 hours
• • Informed consent obtained from parents/guardians
• Exclusion Criteria:
• • Cardiovascular, respiratory, neurological, metabolic, or endocrine disorders
• • Premature birth with corrected age \< 2 years
• • Obesity or severe malnutrition (BMI \<5th or \>95th percentile)
• • Psychiatric or neurodevelopmental disorders (e.g., autism)
• • Malignant hyperthermia or hypersensitivity to anesthetics
• • Emergency surgeries
• • Lack of IV access requiring inhalational induction
• * Contraindications to low-flow anesthesia including:
• • Severe pulmonary disease
• • Congenital heart disease with shunt physiology
• • Anticipated high oxygen demand
• • Airway obstruction risk
• • Surgeries requiring high gas flow or \>6 hours duration