Correlation and Predictive Research of Metal Elements in Radiation-Induced Oral Mucositis

Launched by NANFANG HOSPITAL, SOUTHERN MEDICAL UNIVERSITY · May 5, 2025

Keywords

ClinConnect Summary

This clinical trial is studying how certain metal elements in the body might be related to a painful condition called Radiotherapy-Induced Oral Mucositis (RIOM) that many patients face when undergoing treatment for head and neck tumors. RIOM can cause significant discomfort, making it difficult for patients to continue their treatment and affecting their overall quality of life. The researchers aim to better understand the connection between these metal elements and the severity of RIOM, hoping to find ways to predict who might develop this condition and how severe it may be.

To participate in this study, individuals must be between 18 and 75 years old, have been diagnosed with nasopharyngeal carcinoma or other head and neck tumors, and are planning to receive radiotherapy. They should be in generally good health, without serious other health issues that could complicate treatment. If you join this trial, you will be monitored closely to see how metal levels in your body change during radiotherapy and how that relates to any oral issues you may experience. This research could lead to better strategies for preventing and treating RIOM in the future.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1）Sign the informed consent form; 2) Confirmed by pathological biopsy as nasopharyngeal carcinoma or head and neck tumors; 3) Have indications for radiotherapy and voluntarily accept radiotherapy; 4) ECOG PS: 0/1; 5) Age: 18-75 years old; 6) Laboratory tests confirm good organ function.
• Exclusion Criteria:
• • 1. There are contraindications for radiotherapy;
• • 2. Combined with other tumors;
• • 3. Pathological sections could not be obtained;
• • 4. The patient has any serious concurrent diseases that may pose unacceptable risks or have a negative impact on trial compliance. For instance, unstable heart diseases requiring treatment, chronic hepatitis, kidney diseases with poor conditions, uncontrolled diabetes (fasting blood glucose greater than 1.5 × ULN), and mental disorders;
• • 5. The researcher judged that it was not suitable to participate in this study.