Topical Estrogen: Brief Intervention to Improve Postoperative Experience for Transgender Men Undergoing Hysterectomy
Launched by WOMEN AND INFANTS HOSPITAL OF RHODE ISLAND · May 8, 2025
Trial Information
Current as of June 26, 2025
Recruiting
Keywords
ClinConnect Summary
This clinical trial is studying whether applying a single dose of topical estrogen cream at the end of a hysterectomy (a surgery to remove the uterus and cervix) can help improve recovery for transgender men. The researchers want to find out if using this cream can reduce postoperative bleeding and help alleviate feelings of discomfort or distress, known as dysphoria, that some patients might experience after surgery. Currently, topical estrogen is not routinely used after this type of surgery, so this study aims to determine if it should be part of standard care.
To participate in this trial, you need to be a transgender man, at least 18 years old, and have been on testosterone for at least six months before your planned hysterectomy. You should be in stable physical and mental health and have no known allergies to estrogen. If you join the study, you'll receive either the estrogen cream or a standard treatment during your surgery, and researchers will follow up with you through text messages to monitor your recovery. Your participation will help assess whether this treatment could benefit others in the future.
Gender
FEMALE
Eligibility criteria
- Inclusion Criteria:
- • 1. Gender diverse/transgender men
- • 2. Age 18 or older
- • 3. Have been on testosterone for at least 6 months with plan to undergo gender-affirming hysterectomy and are willing to be randomized to the use of topical estrogen postoperatively.
- • 4. Have stable physical and mental health
- • 5. No contraindications to estrogen therapy
- • 6. Must be proficient in English or Spanish
- • 7. Must have access to a device to receive text messages for study follow up
- • 8. Must agree to allow their medical data to be used for research purposes
- Exclusion Criteria:
- • 1. Under age 18
- • 2. Have not been on testosterone for at least 6 months prior to planned hysterectomy
- • 3. Known allergy to topical estrogen
About Women And Infants Hospital Of Rhode Island
Women & Infants Hospital of Rhode Island is a leading healthcare facility dedicated to the comprehensive care of women and infants, with a strong focus on research and clinical trials aimed at advancing maternal and neonatal health. As a prominent academic medical center affiliated with Brown University, the hospital leverages its expertise in obstetrics, gynecology, and pediatrics to conduct innovative clinical trials that address critical health issues facing women and infants. Committed to improving patient outcomes through evidence-based practices, Women & Infants Hospital fosters a collaborative environment that encourages the integration of cutting-edge research into clinical care, ultimately enhancing the quality of life for its patients and the broader community.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Providence, Rhode Island, United States
Patients applied
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported