Association of Vitamin D Status With Metabolic Markers in Adolescents With Polycystic Ovary Syndrome

Launched by BAGCILAR TRAINING AND RESEARCH HOSPITAL · May 6, 2025

Keywords

ClinConnect Summary

This clinical trial is studying how vitamin D levels relate to metabolic health in adolescent girls with polycystic ovary syndrome (PCOS). PCOS is a condition that affects hormone levels and can cause irregular periods and other symptoms. The researchers want to see if low vitamin D levels are connected to issues like insulin resistance and increased body fat in these girls. They are comparing 70 adolescents with PCOS to 40 healthy girls of the same age to better understand these relationships and the potential health risks associated with PCOS.

To participate in the study, girls aged 12 to 19 who have started their periods at least two years ago may qualify. Those with PCOS must have irregular menstrual cycles and signs of high male hormones, while healthy participants should have regular cycles and no signs of hormone imbalance. Participants can expect to undergo blood tests to check their vitamin D levels and other health markers, as well as measurements of their body fat. It's important to note that girls currently taking certain medications or with specific health conditions are not eligible for this trial. This research aims to provide insights that could help improve the health of adolescents with PCOS.

Gender

FEMALE

Eligibility criteria

• Inclusion Criteria:
• • Female adolescents aged 12 to 19 years
• • Having attained menarche at least two years prior to enrollment
• • For PCOS group: Diagnosis of polycystic ovary syndrome based on NIH criteria (presence of menstrual irregularity and clinical and/or biochemical hyperandrogenism)
• • For Control group: Regular menstrual cycles (cycle interval 21-35 days) and no clinical or biochemical signs of hyperandrogenism.
• Exclusion Criteria:
• • Use of medications affecting vitamin D metabolism, insulin sensitivity, or androgen levels within the past 6 months (e.g., oral contraceptives, insulin sensitizers, vitamin D supplements)
• • Presence of endocrine disorders such as congenital adrenal hyperplasia, hyperprolactinemia, Cushing's syndrome, thyroid dysfunction.
• • Chronic systemic diseases (e.g., diabetes mellitus, severe liver or kidney disease).