IMPACT OF SUPPLEMENTATION WITH LOW MOLECULAR WEIGHT HYDROLYZED COLLAGEN AND VERISOL ON THE EXPRESSION OF LINES, SKIN QUALITY, AND LEVELS OF KLOTHO, VEGF, AND TGF-BETA IN THE EYE REGION

Launched by FEDERAL UNIVERSITY OF SÃO PAULO · May 13, 2025

Keywords

ClinConnect Summary

This clinical trial is studying how different types of collagen supplements can affect skin health, particularly in the eye area, for middle-aged women. As our skin ages, it can develop wrinkles and lose its elasticity due to a decrease in collagen production. The trial will involve 150 women aged 35 to 58 who have not been physically active for at least a year. Participants will be randomly assigned to take one of three types of collagen supplements daily for three months. Researchers will assess improvements in skin qualities such as hydration, oiliness, flexibility, and the appearance of expression lines.

To be eligible for the trial, women must meet certain criteria, including being within the specified age range and agreeing to participate after understanding the study details. However, those who have recently had certain cosmetic procedures, smoked in the past three years, or used specific skin-repairing products will not be included. Participants can expect to undergo evaluations on their skin's condition and may contribute to important research that could help understand the benefits of collagen for skin health.

Gender

FEMALE

Eligibility criteria

• Inclusion Criteria:
• • "Inclusion criteria require that volunteers be between 35 and 58 years old, have been sedentary for at least one year, and, after reading and understanding all stages of the study, agree to and sign the informed consent form (ICF).
• Exclusion Criteria:
• • "Exclusion criteria include undergoing facial aesthetic procedures involving hyaluronic acid or botulinum toxin, being an active or passive smoker within the past 3 years, using protein- or amino acid-based supplements within the past 6 months, or using cosmetics with skin-repairing properties in the orbicularis oculi region.