Causes of Secondary and Prolonged Fever During Treatment of Bacterial Meningitis and Viral Encephalitis

Launched by ASSIUT UNIVERSITY · May 10, 2025

Keywords

ClinConnect Summary

This clinical trial is studying why some children develop a fever that lasts longer than expected during treatment for bacterial meningitis or viral encephalitis. Meningitis is an infection of the protective membranes covering the brain and spinal cord, while encephalitis is swelling of the brain. The researchers want to understand the causes of these fevers in children aged one month to 18 years who are receiving treatment at Assiut University Children's Hospital.

To join the study, children must have been diagnosed with either bacterial meningitis or viral encephalitis and be admitted to the hospital. They should also have a fever that persists despite receiving the right treatment. However, children with certain health conditions, such as autoimmune diseases or those on medications that weaken their immune system, will not be included. Participants in the trial will help doctors learn more about these fevers, which may lead to better treatments in the future.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Children from one month to 18 years.
• • Who were diagnosed with bacterial meningitis or viral encephalitis and admitted to neurological department at Assiut University Children's Hospital (AUCH).
• • Develop secondary or prolonged fever despite appropriate treatment.
• Exclusion Criteria:
• • Pediatric patients with suspected autoimmune encephalitis.
• • Patient on immunosuppressive therapy (e.g., post-organ transplant, chemotherapy).
• • Pediatric patients suspected metabolic disorders.
• • Those with suspected endocrine dysfunction.