Tolerance Through Mixed Chimerism (Sip-Tego)

Launched by TATSUO KAWAI, MD, PHD · May 7, 2025

Keywords

ClinConnect Summary

The Sip-Tego trial is a research study aimed at exploring a new treatment approach for patients with kidney failure who are receiving a kidney transplant. This study will involve six adult participants who are at the end stage of kidney disease and have not shown signs of prior sensitization to donor kidneys. The main goal is to see if the Sip-Tego treatment can help the body accept the new kidney without the need for long-term immunosuppressive drugs, which are medications that prevent the body from rejecting the transplant.

To be eligible for the trial, participants need to be between 18 and 65 years old, have severe kidney disease requiring dialysis, and be preparing for a kidney transplant from a living donor. They also need to be able to understand the study and provide their consent. Participants will undergo a thorough screening process to ensure they meet all the necessary health criteria. While the trial is not yet recruiting, those who participate can expect to receive close monitoring and support throughout the study to ensure their safety and well-being.

Gender

ALL

Eligibility criteria

• Recipient Inclusion Criteria:
• • 1. Male or female 18-65 years of age.
• • 2. Subjects with chronic kidney disease stage V (GFR\<15ml/min/1.73m2) or ESRD who are treated or imminently be treated with either hemodialysis or peritoneal dialysis.
• • 3. Candidate for a living-donor renal allograft from an HLA matched or mismatched donor
• • 4. First or second renal transplant.
• • 5. EBV Seropositive
• • 6. Use of FDA-approved methods of contraception by all recipients from the time that study treatment begins until 104 weeks (24 months) after renal transplantation
• • 7. Ability to understand and provide informed consent.
• • 8. Negative COVID-19 test during screening and two days prior to procedure
• Recipient Exclusion Criteria:
• • 1. ABO blood group-incompatible renal allograft
• • 2. Participant with a donor-specific antibody (DSA) within 6 months prior to transplant
• • 3. Persistent Leukopenia (WBC less than 2,000/mm3) or thrombocytopenia (\<100,000/mm3)
• • 4. Seropositivity for HIV-1, hepatitis B core antigen, or hepatitis C virus (confirmed by hepatitis C virus RNA); or positivity for hepatitis B surface antigen.
• • 5. Untreated Infection
• • 6. Left ventricular ejection fraction \< 40% as determined by TTE or clinical evidence of heart failure.
• • 7. Forced expiratory volume FEV1 or DLCO \< 50% of predicted.
• • 8. Lactation or pregnancy.
• • 9. Patients with active cancer or those with a high risk of recurrence following the American Transplant Society
• • 10. Underlying renal disease etiology with a high risk of disease recurrence in the transplanted kidney (such as non-genetic primary focal segmental glomerulosclerosis dense deposit disease, C3 glomerulonephritis, and, atypical hemolytic uremic syndrome).
• • 11. Prior dose-limiting radiation therapy for treatment of malignant disease.
• • 12. Known genetic disease or family history that may result in greater sensitivity to the effects of irradiation, or a physical deformity that would preclude adequate shielding or appropriate dosing during the irradiation component of the conditioning regimen. This includes long term cigarette smoking or a family history of malignancy.
• • 13. Enrollment in other investigational drug studies within 30 days prior to enrollment.
• • 14. Abnormal (\>2 times lab normal) values for (a) liver function chemistries (ALT, AST, AP), (b) bilirubin, (c) coagulation studies (PT, PTT) , or any patients on chronic anticoagulation therapy.
• • 15. Allergy or sensitivity to any component of Cyclophosphamide, tacrolimus, Siplizumab, Tegoprubart, or rituximab.
• • 16. The presence of any medical condition that the investigator deems incompatible with participation in the trial. This includes a history of alcohol abuse or illicit drug use/dependence.
• • 17. Any chronic or intermittent administration of immunosuppressant medication (such as for inflammatory bowel disease or asthma)
• • 18. Subjects who have non-insulin dependent diabetes (NIDDM) without good blood glucose control (HbA1c\<8%). Subjects with severe diabetes-related complications, such as advanced retinopathy, gastroparesis, or severe neuropathy that significantly impair their ability to perform normal, independent daily activities, will also be excluded.
• Donor Inclusion Criteria:
• • 1. Male or female 18-70 years of age.
• • 2. For females of childbearing potential: a serum pregnancy test showing negative results.
• • 3. Excellent health per conventional pre-donor workup (medical and psychosocial evaluation)
• • 4. Acceptable laboratory parameters (hematology in normal or near-normal range; Liver function \<2 times the upper limit of normal, and normal creatinine).
• • 5. Negative for viral infection with HBV (HbsAg and NAT), HIV (antibody and NAT), HCV (NAT), or HTLV-1.
• • 6. Cardiac/pulmonary function within normal limits (CXR, ECG).
• • 7. Ability to understand and provide informed consent.
• • 8. Meets standard institutional criteria for bone marrow aspiration and kidney donation.
• • 9. Negative COVID-19 test during screening and two days prior to procedure