The Effect of rs7903146 Genotype on Islet GLP-1 Production in Humans

Launched by MAYO CLINIC · May 13, 2025

Keywords

ClinConnect Summary

This clinical trial is studying how a specific genetic variation (called rs7903146) affects the production of a hormone called GLP-1 in people with early type 2 diabetes. Researchers want to understand if this genetic factor impacts how the pancreas works, especially in relation to blood sugar levels. They are particularly interested in people who have either the TT or CC genotype at this location in their genes.

To be eligible for this study, participants need to be between 25 and 70 years old and must not be taking any diabetes medications. People with certain health conditions or previous surgeries that affect the digestive system may not qualify. If you join the trial, you will provide information about your health, and the researchers will monitor how your body responds in relation to your genetic makeup and GLP-1 production. This trial is not yet recruiting participants, but it aims to contribute valuable knowledge about how genetics can influence diabetes management.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Subjects with the TT or CC genotype at rs7903146
• Exclusion Criteria:
• • 1. Age \< 25 or \> 70 years (to avoid studying subjects who could have latent type 1 diabetes, or the effects of age extremes in subjects with normal or impaired fasting glucose).
• • 2. CT genotype at rs7903146
• • 3. HbA1c \> 6.5%
• • 4. Use of any glucose-lowering agents including metformin or sulfonylureas.
• • 5. For female subjects: positive pregnancy test at the time of enrollment or study.
• • 6. History of prior upper abdominal surgery such as adjustable gastric banding, pyloroplasty and vagotomy.
• • 7. Active systemic illness or malignancy.
• • 8. Symptomatic macrovascular or microvascular disease.