Blood Flow Restriction and Transcutaneous Electrical Nerve Stimulation on Motor Function in Stroke

Launched by THE HONG KONG POLYTECHNIC UNIVERSITY · May 7, 2025

Keywords

ClinConnect Summary

This clinical trial is looking at ways to improve leg function in people who have had a stroke, particularly those who still face challenges with mobility. The study explores whether combining low-intensity resistance training with two techniques—blood flow restriction (BFR) and transcutaneous electrical nerve stimulation (TENS)—can help stroke survivors regain better movement in their legs. Participants will be divided into four groups to receive different combinations of these treatments during exercise sessions, which will include leg exercises and cycling, three times a week for six weeks.

To be eligible for this study, participants should be between 50 and 80 years old, have had a stroke at least six months ago, and be able to walk independently for a short distance. They should also be able to follow instructions and not have any serious other health issues that could interfere with the study. Throughout the trial, researchers will measure how well the treatments work by assessing leg function, strength, balance, and other important factors. Participants can expect to engage in targeted exercises and receive personalized care to help improve their mobility and overall quality of life.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. are between 50 and 80 years of age;
• • 2. have had a single stroke more than 6 months and less than 15 years;
• • 3. have at least 5 degrees of active ankle dorsiflexion in the antigravity position;
• • 4. are able to walk 10 m independently, with or without a walking aid;
• • 5. are able to score 6 or higher out of 10 on the abbreviated mental test;
• • 6. have no skin allergies (e.g. redness or itchiness after application of the electrical stimulation pads) to electrical stimulation or electrodes;
• • 7. are able to follow instructions and give informed consent.
• Exclusion Criteria:
• • 1. presence of other comorbidities like varicose veins, peripheral neuropathy, cancer, musculoskeletal injury, lower limb peripheral edema, post-surgical swelling, open wounds, or on a medication that increases blood clotting risk;
• • 2. resting blood pressure ≥ 160/100 mmHg even after taking medications, cardiovascular comorbidity, heart failure, unstable angina, by-pass surgery, a pacemaker;
• • 3. administration of botulinum toxin in the lower limb at least 6 months prior to training;
• • 4. history of epilepsy, cochlear implants, any type of deep brain stimulator and metal implants in the head or neck;
• • 5. currently not participating in resistance training or high-intensity or long duration cardiovascular exercise;
• • 6. lack the ability to feel pain (because of paralysis), or other subjects who cannot complain of discomfort.