Evaluation of Genetic Abnormalities Amongst Calcium Phosphate Stone Formers

Launched by RYAN L STEINBERG · May 7, 2025

Keywords

ClinConnect Summary

This clinical trial, called Calcium Phosphate Stone Genetics, is looking into the genetic factors that may influence the formation of calcium phosphate kidney stones, which are a less common type of kidney stone. Many people develop kidney stones, and while family history seems to play a role, researchers are trying to determine whether it's due to genetics or family eating habits. The study aims to identify any genetic abnormalities in patients who have alkaline urine and form calcium phosphate stones, which can make managing their condition challenging. Participants will be offered free genetic testing through a simple blood draw, and researchers will also look at existing health information to find connections between genetic factors and urine tests.

To be eligible for the trial, participants should be between 18 and 90 years old, under the care of a urologist at the University of Iowa Health Care, and have a history of kidney stones made up of at least 60% calcium phosphate. They must also have a urine pH of 6.3 or higher. However, certain individuals, such as those over 90 or with specific health conditions, may not qualify. If you take part in this study, you'll be contributing to important research that could help improve prevention and management of kidney stones for people like you in the future.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Any patient, aged 18-90 and not incarcerated, under the care of a urologist at UIHC with known kidney stone composition including \>=60% calcium phosphate and baseline 24 hour urine pH of \>=6.3
• Exclusion Criteria:
• • - Any patient over the age of 90 years old, incarcerated or without any evidence of calcium phosphate stone composition
• • No struvite component on prior stone analysis
• • No bacteria with urease producing organism at time of stone removal
• • No history or evidence of systemic acidosis
• • No use of acetazolamide, topiramate, zonisamide, valproic acid
• • Stage \>=3 CKD (GFR\<60)
• • Hepatic disease
• • Pregnancy
• • History of osteoporosis