Effect of Magnesium on Neuromonitoring

Launched by UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · May 7, 2025

Keywords

ClinConnect Summary

This clinical trial is studying how magnesium affects a specific type of monitoring used during spine surgery called Transcranial Motor Evoked Potentials (TcMEPs). TcMEPs help doctors ensure that the nerves are working properly during surgery, which is important for patient safety. The trial aims to understand how different levels of magnesium in the blood can influence the effectiveness of this monitoring. Magnesium is often used to help reduce pain and the need for stronger pain medications after surgery.

To be eligible for this trial, participants should be adults over 18 years old who are undergoing a specific type of spine surgery called thoracolumbar fusion with neuromonitoring. However, individuals with certain health conditions, like serious heart or kidney diseases, or those who are allergic to magnesium, will not be included. Participants in this study will receive magnesium during their procedure, and researchers will monitor how it impacts nerve function during surgery. This trial is important because it aims to provide more information about using magnesium in spine surgery, ensuring better care for future patients.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Adult patients (\>18 years of age) undergoing open thoracolumbar fusion with planned neuromonitoring
• Exclusion Criteria:
• • 1. Patients with a history of significant cardiac disease (LVEF \<35%, 2nd/3rd-degree block without a pacemaker, or significant arrhythmia)
• • 2. Patients with kidney disease (GFR \<30), or hepatic dysfunction (history of cirrhosis)
• • 3. Allergy or sensitivity to magnesium
• • 4. Patient with neuromuscular disease such as myasthenia graves