Extubation Safety Via Microstream EtCO₂ (IPI) Monitoring

Launched by CHINESE PLA GENERAL HOSPITAL · May 15, 2025

Keywords

ClinConnect Summary

This clinical trial is looking at a new way to safely take a breathing tube out of patients who have just had surgery under general anesthesia. The researchers want to see if using a special monitoring system called the Integrated Pulmonary Index (IPI), which tracks carbon dioxide levels in the breath, can help reduce low oxygen levels (hypoxemia) after the tube is removed. They will compare patients who are monitored with IPI to those who follow standard procedures to find out which method leads to better results and fewer complications, like heart problems or prolonged low oxygen.

To participate, patients need to be scheduled for elective abdominal surgery and be between 18 and 80 years old. They will be randomly placed in one of two groups: one group will have their breathing monitored with the IPI system, while the other will follow the usual extubation methods without this monitoring. After the breathing tube is removed, the researchers will check how well patients are doing and gather feedback from them and the nursing staff about their experiences. This study aims to improve safety and comfort for patients recovering from surgery.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. Patients scheduled for elective abdominal surgery (gastrointestinal surgery in general surgery, gynecology, hepatobiliary surgery, or urology) under general anesthesia with endotracheal intubation in the PACU of the First Medical Center of the PLA General Hospital between April 2025 and April 2026, with ASA classification I-III, aged ≥18 years and \<80 years, and surgical duration ≥1 hour and ≤4 hours.
• • 2. Signed informed consent form
• Exclusion Criteria:
• • 1. Patients whose endotracheal tube had been removed before entering the PACU.
• • 2. Patients with preoperative room-air SpO₂ \< 95%, or those who failed to enter the PACU postoperatively for any reason.
• • 3. Patients with a history of sleep apnea.
• • 4. Patients undergoing a second surgery within one month.
• • 5. Patients with a history of neuromuscular dysfunction.
• • 6. Patients with psychiatric or cognitive disorders; a history of abuse of psychotropic or anesthetic drugs; or communication barriers.
• • 7. Patients unable to cooperate with the clinical trial.
• The exclusion criteria are as follows:
• • 1. Patients with severe arrhythmia after entering the PACU.
• • 2. Patients whose extubation is delayed due to medical conditions (e.g., awaiting frozen section results, active bleeding, etc.) after entering the PACU.
• • 3. Patients who require a second surgery after extubation in the PACU.-