Study on the Mechanism of Multi-group Analysis of the Influence of Depression on Common Cardiovascular Diseases

Launched by FIRST AFFILIATED HOSPITAL OF HARBIN MEDICAL UNIVERSITY · May 8, 2025

Keywords

ClinConnect Summary

This clinical trial is studying the connection between depression and heart diseases, which are major health issues affecting millions of people worldwide. Researchers want to understand how depression might increase the risk of heart problems like heart attacks and strokes, as well as how changes in gut bacteria may play a role in this connection. To do this, they will gather information from three groups of participants: healthy individuals, people with depression, and those with both depression and heart disease. By analyzing samples like stool, blood, and saliva, the study hopes to uncover important insights that could help in preventing and treating cardiovascular diseases linked to depression.

To be eligible for this trial, participants should be between certain age limits and belong to one of the three groups mentioned. For example, those in the depression group must be newly diagnosed and not have taken any psychiatric medications recently. Throughout the study, participants will be monitored for several years to track their health outcomes. This research is significant because it aims to provide better treatment options and identify potential markers for cardiovascular diseases associated with depression, ultimately improving care for those affected.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. Healthy control group 1) Good health and no gastrointestinal diseases; 2) No previous history of mental illness; 3) No previous history of cardiovascular disease;
• • 2. Depression group
• • 1) Meet the diagnostic criteria of the latest guidelines for depression, and be clinically diagnosed by at least two psychiatrists; 2) Patients with first-episode depression; 3) Have not taken any psychoactive drugs before or have not taken any psychoactive drugs within 4 weeks.
• • 3. Depression with cardiovascular disease group
• • 1. Meet the diagnostic criteria of the latest guidelines for depression, and be clinically diagnosed by at least two psychiatrists;
• • 2. Patients with first-episode depression;
• • 3. Have not taken any psychoactive drugs before or have not taken any psychoactive drugs within 4 weeks.
• • 4. There is definite clinical evidence of heart failure, coronary heart disease, hypertension or arrhythmia.
• Exclusion Criteria:
• • 1. Have a history of alcohol dependence, organic brain diseases, nervous system diseases and other complex mental diseases;
• • 2. Long-term use of psychoactive drugs/use of psychoactive drugs within 4 weeks;
• • 3. Patients with thyroid dysfunction
• • 4. Patients with severe liver and kidney dysfunction;
• • 5. Patients with chronic obstructive pulmonary disease, interstitial pulmonary fibrosis and pulmonary hypertension;
• • 6. Patients with autoimmune diseases and tumors;
• • 7. used antibiotics, yogurt or other drugs or foods that affect intestinal flora within 4 weeks;
• • 8. Pregnant or lactating women;
• • 9. There is a serious impairment of cognitive function, which makes it impossible to cooperate with the research procedure;
• • 10. Have received invasive medical procedures such as gastroscopy and colonoscopy in the past three months;
• • 11. The diet has changed greatly in the past week;
• • 12. Participate in simultaneous clinical trials;
• • 13. Refuse to sign the informed consent for participating in the experiment.