Application of a Prediction Model for Directing Antibiotic Use in the Treatment of Urinary Tract Infection in an Ambulatory Setting
Launched by CASE WESTERN RESERVE UNIVERSITY · May 9, 2025
Trial Information
Current as of June 27, 2025
Not yet recruiting
Keywords
ClinConnect Summary
This clinical trial is looking at how to use a special prediction model to help doctors decide when to prescribe antibiotics for urinary tract infections (UTIs) in women who are discharged from the emergency room. UTIs can cause uncomfortable symptoms like burning during urination and a frequent urge to go to the bathroom. Often, patients receive antibiotics right away when they leave the ER, but this trial aims to reduce unnecessary antibiotic use. Overusing antibiotics can lead to antibiotic resistance, making infections harder to treat in the future.
To participate in this study, women over 18 years old who have been diagnosed with a UTI and prescribed antibiotics at the emergency room may be eligible. Participants will be monitored to see if the prediction model can help avoid unnecessary antibiotic prescriptions while still effectively managing their condition. It’s important to know that the study will not include men or patients who have certain medical conditions or high levels of pain. Overall, this research aims to promote smarter antibiotic use, which is better for both individual health and public health.
Gender
FEMALE
Eligibility criteria
- Inclusion Criteria:
- • Female sex
- • Age \>18 years old
- • Discharged from the hospital after ER visit
- • Discharge ICD code consistent with a UTI diagnosis
- • Antibiotic prescribed for UTI at the time of discharge
- Exclusion Criteria:
- • Male sex
- • Necessity for chronic bladder catheterization or discharge with a urinary catheter
- • Patients who have an Emergency Severity Index (ESI) of 1 and 2
- • Patients who verbalize to the study team member that their pain is a 6 or higher
- • Patient set to be transferred to inpatient care
- • History of bladder augmentation
- • Pregnancy (this will be confirmed with a negative pregnancy test which is ordered in the ER)
About Case Western Reserve University
Case Western Reserve University (CWRU) is a leading research institution located in Cleveland, Ohio, renowned for its commitment to advancing knowledge and improving health outcomes through innovative clinical research. With a strong emphasis on interdisciplinary collaboration, CWRU integrates expertise from various fields, including medicine, engineering, and social sciences, to address complex health challenges. The university's clinical trial initiatives are designed to foster the development of novel therapies and interventions, ensuring rigorous scientific methodologies and ethical standards are upheld. CWRU is dedicated to translating research findings into tangible benefits for patients and communities, contributing significantly to the advancement of healthcare practices and policies.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Cleveland, Ohio, United States
Patients applied
Trial Officials
David Sheyn, MD
Principal Investigator
University Hospitals Cleveland Medical Center
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported