Study for Remote Investigation of Evaporative Dry Eye Disease

Launched by UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · May 8, 2025

Keywords

ClinConnect Summary

This clinical trial, called the Study for Remote Investigation of Evaporative Dry Eye Disease, aims to explore how well different treatments work for people suffering from evaporative dry eye disease, a condition that makes your eyes feel dry and uncomfortable. Unlike traditional studies that require visits to a doctor’s office, this trial allows participants to take part from home, making it easier for more people to join and share their experiences.

To be eligible for this study, you need to be at least 18 years old and have been diagnosed with evaporative dry eye disease, which means your eyes may not produce enough tears, but there shouldn’t be any significant issues with your tear production. Both men and women can participate, and there are no restrictions based on race or ethnicity, so everyone is welcome. Since this trial does not involve giving any treatments, it poses no risk to pregnant women who wish to enroll. Participants will be asked to monitor their own symptoms and tear production from home, which means having internet access and being comfortable with some basic self-measurements. Overall, this study hopes to improve understanding and treatment of dry eye disease for everyone.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Evaporative loss dry eye disease will be confirmed by screening clinical examination. Patients with evaporative loss dry eye disease will have minimal to no corneal staining and have normal aqueous (water) tear production. Eligible patients with evaporative loss dry eye disease over the age of 18 will be offered study participation.
• • There will be no ethnic restrictions on enrollment. All adults (18 years of age or older) with evaporative loss dry eye disease regardless of race or ethnicity will be recruited for participation.
• • All adults (18 years of age or older) with evaporative loss dry eye disease , regardless of sex/gender are eligible for recruitment. Women will not be excluded if they are pregnant or breastfeeding.
• • All adults age 18 or older with evaporative loss dry eye disease will be recruited for participation. Dry eye disease is not common in the pediatric population and younger children would require assistance with electronic symptom logging and self-performed ocular surface sample collection. Therefore, this study of feasibility of decentralized dry eye disease study will exclude children.
• • No treatment is administered in this non-interventional feasibility trial, therefore if pregnant women have dry eye they can participate with no risk to the fetus.
• Exclusion Criteria:
• • Patients with keratoconjunctivitis sicca (clinically significant decrease in aqueous production) will not be included. This is because the population with this dry eye disease subtype is at higher risk for corneal epithelial breakdown and ocular surface infection.
• • Patients unwilling to measure their own tear production at home will be excluded.
• • Patients without internet access or reasonable proximity/access to a post box will be excluded.
• • Eyedrop use is not an exclusion criterion.