Heart Rate Variability as a Predictor of Rebound Pain Following Total Knee Arthroplasty

Launched by KONYA CITY HOSPITAL · May 14, 2025

Keywords

ClinConnect Summary

This clinical trial is looking into whether heart rate variability (HRV) can help predict rebound pain after total knee replacement surgery, which is when patients experience sudden, intense pain after their initial pain relief has worn off. By measuring HRV with a heart monitor before and after surgery, researchers hope to find out if this measurement can be used to anticipate rebound pain and improve pain management strategies for patients.

To be eligible for the study, participants should be between 18 and 70 years old and scheduled for a planned total knee replacement surgery using spinal anesthesia. They should be in good overall health, as indicated by a physical status of I-III, and be able to provide written consent and complete pain questionnaires. Participants will be asked to track their pain levels, medication use, sleep quality, and satisfaction with their care. This study is not yet recruiting, but the findings could help tailor pain management plans for future knee surgery patients.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Age between 18 and 70 years
• • American Society of Anesthesiologists (ASA) physical status I-III
• • Scheduled for elective, unilateral total knee arthroplasty under spinal anesthesia
• • Planned use of multimodal analgesia including peripheral nerve blocks
• • Ability to provide written informed consent
• • Ability to understand and complete pain diaries and questionnaires
• Exclusion Criteria:
• • Known allergy to local anesthetics
• • Contraindications to regional anesthesia
• • Contraindications to spinal anesthesia
• • ASA physical status IV or higher
• • Pregnancy or breastfeeding
• • Neurological or psychiatric disorders impairing ability to participate or report outcomes
• • Use of anticoagulant therapy or presence of coagulation disorders
• • Infection at the proposed injection site
• • Emergency (non-elective) surgical procedures