Physical Activity on Neuroinflammation in Parkinson's Disease
Launched by IRCCS NATIONAL NEUROLOGICAL INSTITUTE "C. MONDINO" FOUNDATION · May 14, 2025
Trial Information
Current as of July 25, 2025
Recruiting
Keywords
ClinConnect Summary
This clinical trial is exploring how regular intense physical exercise can help patients with Parkinson's Disease (PD) by looking specifically at its effects on inflammation in the body. Parkinson's is a progressive condition that affects movement and can cause symptoms like tremors and stiffness. The study aims to compare two groups of participants: one group will engage in regular intense exercise, while the other group will remain sedentary. Researchers hope to find out if the exercising group has less inflammation in their bodies, which could lead to improvements in their overall health and quality of life.
To be eligible for the trial, participants must be between 40 and 80 years old and have a confirmed diagnosis of Parkinson's Disease that falls within a certain range of severity. Certain health conditions, such as other neurological diseases or significant cognitive decline, may exclude individuals from participating. Those who join the study can expect to follow a structured exercise program and share their experiences, contributing to important research that could benefit many others living with Parkinson's Disease.
Gender
ALL
Eligibility criteria
- Inclusion Criteria:
- • Subjects of both sexes, aged between 40 and 80 years (extremes included)
- • Diagnosis of Parkinson's disease according to the clinical diagnostic criteria of the Movement Disorder Society
- • Hoehn \& Yahr between 1 and 3
- Exclusion Criteria:
- • Concomitant diagnosis of other neurological diseases
- • Presence of confirmed cognitive decline (MMSE \< 24)
- • Presence of depression with (BDI \> 40)
- • Patients with deep brain stimulation implant or undergoing DuoDopa therapy
- • Presence of significant diseases affecting the musculoskeletal system
- • Presence of internal medicine conditions, considered clinically significant by the investigator
- • Acute or recent infections
- • Body Mass Index (BMI) \>= 30
- • Active smoking behavior
- • Ongoing treatment with N-acetylcysteine or anti-oxidants
- • Pregnancy or lactation
About Irccs National Neurological Institute "C. Mondino" Foundation
The IRCCS National Neurological Institute "C. Mondino" Foundation is a prominent research institution in Italy dedicated to advancing the field of neurology through innovative clinical trials and scientific research. As a recognized IRCCS (Istituto di Ricovero e Cura a Carattere Scientifico), the foundation focuses on the diagnosis, treatment, and rehabilitation of neurological disorders, fostering collaboration among healthcare professionals, researchers, and academic institutions. Committed to translating cutting-edge research into clinical practice, the foundation aims to enhance patient care and improve outcomes for individuals affected by neurological diseases. Its rigorous approach to clinical trials ensures the highest standards of scientific integrity and patient safety.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Pavia, , Italy
Patients applied
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported