Managing Congestion in Heart Failure: A Mechanistic Study in Patients With HFpEF

Launched by OTTO-VON-GUERICKE UNIVERSITY MAGDEBURG · May 9, 2025

Keywords

ClinConnect Summary

The MAGIC-HF clinical trial is exploring how daily remote monitoring can improve care for people with heart failure with preserved ejection fraction (HFpEF). The study focuses on using a small device called CardioMEMS™ to measure pressure in the lungs and a smart scale to check body water levels. These daily measurements, which take only about two minutes, will help doctors understand and manage fluid buildup, or congestion, more effectively. By monitoring these factors over six months, the researchers hope to improve heart and kidney function and reduce hospital visits for patients.

To participate in this study, you need to be at least 18 years old and have HFpEF, which means your heart can pump normally but struggles with other issues, causing fluid retention. You should also have been hospitalized recently and treated with diuretics, which help remove excess fluid. However, people with certain serious heart conditions or those who have had recent heart surgeries may not be eligible. Participants will receive comprehensive care involving regular check-ins and blood tests to track their progress, aiming to personalize treatments for better health outcomes.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 18 years of age or older
• • Patients with HFpEF, who are hospitalized for acute decompensated heart failure and require treatment with intravenous (IV) diuretics.
• • Signed informed consent.
• Exclusion Criteria:
• • Patients admitted with cardiogenic shock and/or those who required inotropic or vasopressor support.
• • Had a history of cardiac transplantation or ventricular assist device (VAD) implantation.
• • Had any implanted cardiac device (pacemaker, ICD, CRT-D.
• • Had chronic kidney disease with creatinine clearance \< 20 ml/min.
• • Had recent acute MI or CABG within 3 months.