Dexmedetomidine, Magnesium Sulphate and Lidocaine for Cough Suppression After General Anesthesia

Launched by AL-AZHAR UNIVERSITY · May 16, 2025

Keywords

ClinConnect Summary

This clinical trial is studying how effective three different medications—dexmedetomidine, magnesium sulfate, and lidocaine—are at reducing coughs that can occur after waking up from general anesthesia. Coughing after surgery can be uncomfortable and might affect recovery, so the goal is to find out which of these medications works best to minimize both the number and severity of coughs during this time.

To participate in the trial, you would need to be between 21 and 60 years old, have a healthy body weight (a Body Mass Index or BMI less than 30), and be undergoing surgery that requires general anesthesia. However, if you have certain health conditions, such as a known allergy to any of the medications being tested or significant organ diseases, you would not be eligible to take part. If you join the study, you will be assigned to receive one of the medications or a placebo (a substance with no active ingredients), and neither you nor the researchers will know which one you receive. This helps ensure fair and unbiased results. The trial is not recruiting participants yet, but it aims to help improve patient care during surgery recovery.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Aged 21-60 years.
• • Both genders.
• • Body mass index \< 30 kg/ m2
• • American Society of Anesthesiology (ASA) physical status I-II.
• • Mallampati score class I or II.
• • Patients undergoing surgery under general anesthesia.
• Exclusion Criteria:
• • Known allergy to study drugs.
• • History of psychiatric illness.
• • Patients with major organ diseases.
• • Pre-existing neurological deficits.
• • Body mass index \>30 kg/m2.
• • Active airway infection or history of tracheal and laryngeal surgery.
• • Lower esophageal sphincter incompetence (and reflux).
• • Increased intracranial and intraocular pressure.
• • Use of cough-inducing medications
• • Pregnant, and lactating women.