Enhanced White Light Endoscopy Versus Conventional White Light Endoscopy for Colorectal Adenoma Detection: A Randomized Controlled Trial

Launched by SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE · May 11, 2025

Keywords

ClinConnect Summary

This clinical trial is comparing two different methods of endoscopy, which is a procedure used to look inside the colon, to see which one is better at finding colorectal adenomas, a type of growth that can potentially lead to cancer. The trial will specifically look at Enhanced White Light Endoscopy (E-WLI) and Conventional White Light Endoscopy (WLI) to see how they differ in detecting adenomas and other types of polyps, as well as their characteristics like size and location.

To participate in the trial, you need to be a man or woman aged between 45 and 85 years old who is scheduled for a colonoscopy for reasons such as cancer screening or follow-up after previous polyp treatment. Participants must be able to give their consent and follow the study guidelines. The trial is not yet recruiting, so if you are eligible and interested, keep an eye out for updates on when the study starts. Throughout the trial, participants can expect to undergo a colonoscopy using one of the two methods being studied, which will help researchers understand which method may be more effective in finding polyps.

Gender

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Eligibility criteria

• Inclusion Criteria:
• • 1. Male or female aged 45 to 85
• • 2. Patients undergoing colonoscopy for colorectal cancer screening, positive fecal immunochemical test (FIT) results, gastrointestinal symptoms, or follow-up examination after colorectal polyp treatment
• • 3. Capable of providing informed consent and agreeing to participate
• • 4. Able and willing to follow all research processes
• Exclusion Criteria:
• • 1. Participated in other clinical trials, signed informed consent form, and in the follow-up period of other clinical trials;
• • 2. Participated in clinical trials of drugs and is in the discontinuation period of experimental or control drugs;
• • 3. Have had drug or alcohol abuse or psychological disorders in the past five years.
• • 4. Pregnant or lactating patients;
• • 5. Known to have polyposis syndrome;
• • 6. Patients with gastrointestinal bleeding;
• • 7. Previous history of inflammatory bowel disease, colorectal cancer, or colorectal surgery;
• • 8.Patients with contraindications to tissue biopsy;
• • 9. History of allergies to the ingredients in intestinal cleansers;
• • 10. Individuals with conditions such as intestinal obstruction or perforation, toxic megacolon, heart failure (grade III or IV), severe cardiovascular disease, severe liver failure, or renal insufficiency, among others.
• • 11. Researchers believe that patients are not suitable to participate in the trial.