Research for Plasma Biomarkers Associated With Fatigue in Thrombocytopenic Patients

Launched by ASSISTANCE PUBLIQUE - HÔPITAUX DE PARIS · May 12, 2025

Keywords

ClinConnect Summary

This clinical trial is exploring the link between fatigue and a condition called thrombocytopenia, which is when a person has a low platelet count in their blood. Platelets are important for blood clotting, and when their levels drop below 150,000 per microliter, it can cause various health issues. Many people with thrombocytopenia report feeling very tired, but doctors aren’t sure why. The researchers believe that certain factors found in platelets might be related to this fatigue, particularly a substance called Brain-Derived Neurotrophic Factor (BDNF), which helps support nerve cells in the body.

To participate in this study, adults and children with diagnosed thrombocytopenia can apply, as long as they haven’t received certain treatments in the past few weeks. Healthy volunteers who are similar in age and gender but do not have thrombocytopenia can also take part. Participants will be asked to provide consent after learning about the study, and they'll have the chance to help researchers understand how fatigue affects those with low platelet counts. This research could lead to better care and treatment options for people dealing with thrombocytopenia and its related challenges.

Gender

ALL

Eligibility criteria

• Inclusion criteria for patients (adults or minors):
• • Patients with constitutional or autoimmune (chronic or persistent ITP with last treatment administration ≥ 3 weeks) thrombocytopenia (platelet count \< 150×109/L) already diagnosed
• • patient not being treated and not receiving serotonin reuptake inhibitor (SSRI) or norepinephrine (SNRI) or antithrombotic treatments (antiplatelet or anticoagulant) in the 10 days prior to inclusion
• • affiliation to social security (beneficiary or assignee)
• • patient followed in consultation in one of the recruiting haematology departments
• • Patient (or parent) having received a detailed explanation of the research project and having consent by signing the consent form before any research-specific procedure
• Inclusion criteria for healthy volunteers:
• • Age- (± 5 years) and sex-matched healthy adult controls
• • Non-thrombocytopenic patients and not receiving antithrombotic, SNRI or SSRI therapy or if applicable, last treatment ≥ 10 days
• • affiliation to social security (beneficiary or assignee)
• • adults who received a detailed explanation of the research project and having consent by signing the consent form before any research-specific procedure
• Non inclusion criteria (adults and minors):
• • Adult patients under legal protection (guardianship or curatorship) Thrombocytopenic patients treated with antithrombotics, serotonin reuptake inhibitors (SSRIs) or noradrenaline reuptake inhibitors (SNRIs)
• • Minor patients weighing less than 20 kg
• Non inclusion criteria for healthy adult controls:
• • Healthy adult volunteers under legal protection (guardianship, curatorship or safeguard of justice).
• • Pregnant women