The Effects of Positive End-expiratory Pressure (PEEP) on Optic Nerve Sheath Diameter in Laparoscopic Cholecystectomy

Launched by NIGDE OMER HALISDEMIR UNIVERSITY · May 16, 2025

Keywords

ClinConnect Summary

This clinical trial is studying how a specific breathing technique called positive end-expiratory pressure (PEEP) affects the optic nerve sheath diameter (ONSD) in patients undergoing a type of surgery called laparoscopic cholecystectomy, which involves removing the gallbladder. The goal is to see if applying PEEP can help in understanding changes in pressure inside the brain during surgery. About 80 adults who are generally healthy (with some health conditions allowed) will be involved in this study after they give their consent.

If you join this trial, you'll have your ONSD measured at different times during your surgery using a special ultrasound device. The researchers will also keep track of various other important health indicators, like your breathing and heart rate, throughout the procedure. This study aims to gather important information that could improve the care of patients like you during similar surgeries in the future.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • - Adult patients (age ≥ 18 years)
• • American Society of Anesthesiologists (ASA) physical status I-III
• • Scheduled for elective laparoscopic cholecystectomy under general anesthesia
• • Signed informed consent
• Exclusion Criteria:
• • resence of acute or chronic eye disease
• • Uncontrolled hypertension
• • Asthma or known chronic pulmonary disease
• • Any neurological disorders
• • Body mass index (BMI) \> 35 kg/m²
• • Use of medications known to affect intracranial pressure
• • Refusal to participate after signing informed consent