Ozonized Olive Oil in the Treatment of Periodontal Pockets

Launched by UNIVERSITY OF BARI · May 16, 2025

Keywords

ClinConnect Summary

This clinical trial is investigating the use of ozonized olive oil gel as a treatment for periodontal pockets in patients with chronic periodontitis, which is a serious gum disease. Sixteen participants, both men and women aged 18 and older, will be part of the study. To qualify, participants must have specific levels of gum disease, indicated by a probing pocket depth of 4 mm or more at multiple sites in their mouth. Certain individuals, such as those with severe smoking habits, diabetes, or on specific medications, will not be eligible to ensure safety during the trial.

Participants in the trial will be randomly assigned to one of two groups: one will receive the ozonized olive oil gel, while the other will receive a placebo gel that does not contain the active ingredient. All participants will first receive standard dental cleaning to remove tartar. Over the course of the study, which lasts a few weeks, participants will have their gum health monitored through probing and microbiological samples. This trial aims to see if the ozonized olive oil gel helps improve gum health compared to the placebo. If you or a loved one are interested in participating, you will need to provide informed consent and be willing to attend follow-up appointments for evaluations.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Patients with stage II, III, or IV periodontitis according to the new 2017 World Workshop periodontal classification
• • Patients of either sex and older than 18 years of age
• • Probing Pocket Depth (PPD) greater than or equal to 4 mm at 3 sites
• • Patients who have signed consent to the study
• • Collaborating patients
• Exclusion Criteria:
• • age \< 18 years and/or inability to provide written informed consent;
• • absence of family or social welfare support;
• • non-drug-induced gingival hypertrophy,
• • severe smokers (more than 20 cigarettes per day),
• • consumers of high levels of alcohol,
• • patients on corticosteroid treatment,
• • diabetic patient,
• • immunodepressive therapies,
• • chemotherapies,
• • radiotherapies,
• • pregnancy states;
• • lack of collaboration for ongoing postoperative reevaluations.