Effect of Pre-medication With Anti-inflammatory Drugs(Ibuprofen and Dexamethasone)on Post-Endodontic Pain

Launched by ARMED FORCES INSTITUTE OF DENTISTRY, PAKISTAN · May 17, 2025

Keywords

ClinConnect Summary

This clinical trial is studying how taking anti-inflammatory medications, specifically ibuprofen and dexamethasone, before a dental procedure called endodontics (which treats painful tooth issues) can help reduce pain afterward. It aims to find out if these medications can make the recovery process more comfortable for patients with severe tooth pain caused by inflamed dental pulp.

To join this study, participants should be healthy adults aged 18 to 50, with a permanent tooth that has severe inflammation but no swelling or drainage. They should be willing to attend follow-up appointments and provide written consent. However, people who are currently taking pain medications or antibiotics, have certain dental conditions, or are pregnant or breastfeeding cannot participate. If you qualify and decide to join, you can expect to receive the medications before your dental treatment and then report how you feel afterward, helping researchers understand the effects of these drugs on post-treatment pain.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. Permanent teeth with acutely inflamed pulp without swelling or draining sinus.
• • 2. Patients of either gender aged between 18-50 years old.
• • 3. Systemically healthy patients.
• • 4. Patients who agree to attend for recall appointments and provide a written consent.
• Exclusion Criteria:
• • 1. Patients on preoperative analgesics and antibiotics.
• • 2. Teeth with calcified canals and previously treated teeth.
• • 3. Pregnant and lactating mothers.
• • 4. Patients who are immunocompromised, anxious and mentally handicapped.
• • 5. Patients who are allergic to any of the test medications.