Physical Activity Oxidative Stress and Inflammation With Ageing

Launched by NANTES UNIVERSITY HOSPITAL · May 12, 2025

Keywords

ClinConnect Summary

This clinical trial is investigating how physical activity, oxidative stress (which is an imbalance between free radicals and antioxidants in the body), and inflammation affect older adults, especially in relation to muscle health. The study aims to understand the connection between these factors and how they influence physical performance in individuals aged 70 to 90. Researchers believe that by looking at antioxidant supplements—nutrients that can help reduce oxidative stress and inflammation—they may find new ways to support muscle health in older people.

To participate in this trial, you need to be between 70 and 90 years old and have a scheduled blood test at the Bellier Hospital in Nantes. You should not be severely frail, and must be able to provide consent to join the study. However, certain conditions, like recent weight loss, active cancer, or chronic inflammation, may disqualify you. If you join, you can expect to have your nutritional status and muscle performance assessed, contributing to important research that could help improve the health of older adults as they age.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Male or female, aged 70 to 90, consulting the Nantes CHU CANGC (Bellier Hospital) and who has an indication for a blood test scheduled as part of routine care within 4 months according to the clinician.
• • Clinical Frailty Scale (CFS) score less than or equal to 4 (i.e. threshold for identifying frail elderly people).
• Exclusion Criteria:
• • Opposition to participation in the study
• • Indication for emergency blood sampling in the city
• • Use of a wheelchair or with a proven disability
• • Criteria for undernutrition: weight loss of more than 5% in the last month or more than 10% in the last 6 months and/or BMI strictly less than 22 kg/m2.
• • Tobacco consumption
• • Diabetes
• • Any type of active and/or treated cancer less than 5 years old
• • Chronic inflammation pathology
• • Clinically significant infectious or inflammatory episode ended at least one month ago
• • Long-term or last-month corticosteroid therapy
• • Antioxidants or trace elements taken in the last 3 months
• • Patient not affiliated to a Social Security system
• • Patient deprived of liberty by judicial or administrative decision
• • Patients under guardianship or trusteeship