Hydration To be Optimized (H2O) With a Low-sodium Beverage

Launched by SOCIÉTÉ DES PRODUITS NESTLÉ (SPN) · May 12, 2025

Keywords

ClinConnect Summary

The Hydration To be Optimized (H2O) trial is studying how a new low-sodium beverage containing whey protein and glycerol affects hydration in healthy adults compared to plain water. Researchers want to see if this special drink helps people stay hydrated better. The study will involve 45 healthy adults who are between 18 and 50 years old. To participate, individuals must have a healthy weight and be free from serious medical conditions that could affect their safety during the trial.

Participants in this study will visit the Clinical Innovation Lab in Lausanne three times. During each visit, they will drink one of the test beverages or plain water and complete some assessments. The study is designed to ensure that participants don’t know which drink they are consuming at each visit, making it a fair test. If you think you might be eligible and are interested in helping researchers learn more about hydration, this could be a great opportunity!

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. Female and male adults aged 18-50 years.
• • 2. Body mass index (BMI) between 18.5 to 25 kg/m² (inclusive).
• • 3. Healthy as determined based on self-reported medical history.
• • 4. Able to understand and to sign a written informed consent prior to study enrolment.
• • 5. Willing and able to comply with the requirements for participation in this study.
• Exclusion Criteria:
• • 1. Any past or on-going diagnosed medical/surgical condition (e.g. malignancy, renal condition, liver condition, uncontrolled diabetes mellitus, cardiovascular disease, hypertension, migraine and headache disorders) and/ or psychiatric condition (e.g. depression, psychotic disorders, chronic insomnia, eating disorder), which in the opinion of the site physician/investigator may risk participant's well-being/safety, impede participant compliance with study procedures or ability to complete the study and/or could confound the primary objectives of the study.
• • 2. Current intake of medication/s that impact hydration status (e.g. anti-hypertensive medications, anti-diabetic medications, anti-psychotics, anti-depressants, diuretics, laxatives, antidiuretic hormone (ADH) antagonists, oral corticosteroids, glucocorticoids, anti-cholinergic medications, or cyclosporine A).
• • 3. Currently on a high-protein (1.5g/kg/BW/day) or ketogenic diet (based on self-report).
• • 4. Known/suspected food allergy or intolerance to any food (based on self-report).
• • 5. Female participants who are pregnant, lactating and/or breastfeeding (self-report or if in doubt, via urine pregnancy test).
• • 6. Any self-reported chronic alcohol or drug abuse within the past year; specifically, an average alcohol intake \> 2 standard drinks per day over a week for males, and \> 1 standard drink per day over a week for females. One standard drink contains 10-12 g of ethanol, i.e., 0.3 dl of strong alcohols, 1dl of wine, 3 dl of beer.
• • 7. Currently participating in another interventional study.
• • 8. Family or hierarchical relationships with the research team members.