Caspase-1 Activity, IL-1beta, and IL-18 in Patients With FMF

Launched by HITIT UNIVERSITY · May 13, 2025

Keywords

ClinConnect Summary

This clinical trial is studying a condition called Familial Mediterranean Fever (FMF), which causes repeated episodes of fever and inflammation. The researchers want to learn more about how certain markers in the intestines, specifically Interleukin-1 (IL-1), Interleukin-18 (IL-18), and Caspase-1, might be involved in FMF. To do this, they will collect small tissue samples from the intestines of patients during routine endoscopy (a procedure where a doctor examines the inside of the body) and compare these samples to those from healthy individuals. Understanding these markers could help identify new ways to treat FMF.

To participate in this study, you must be at least 18 years old and have a confirmed diagnosis of FMF. You should be undergoing a routine endoscopy that includes a biopsy, and there needs to be enough tissue available for analysis. However, if you have a history of inflammatory bowel disease, are currently on certain medications that suppress the immune system, or have other serious health issues, you may not be eligible. If you decide to join, you'll help researchers uncover important information that could lead to better treatments for FMF in the future.

Gender

ALL

Eligibility criteria

• • Inclusion Criteria:Age 18 years or older
• • Confirmed diagnosis of Familial Mediterranean Fever (FMF) according to Tel-Hashomer clinical criteria and/or MEFV gene mutation analysis (for FMF group)
• • Undergoing routine endoscopy with mucosal biopsy sampling
• • Availability of sufficient formalin-fixed paraffin-embedded (FFPE) tissue for immunohistochemical analysis
• • For controls: absence of systemic inflammatory or autoimmune disease -
• • Exclusion Criteria:History of inflammatory bowel disease (e.g., Crohn's disease, ulcerative colitis)
• • Current use of immunosuppressive therapy (excluding colchicine)
• • Severe infection, active malignancy, or other systemic disease affecting intestinal mucosa
• • Inadequate biopsy specimen quality for histopathological evaluation
• • -