Effects of Fibres Combined With Probiotics on Uric Acid in an ex Vivo Fermentation Model

Launched by ÖREBRO UNIVERSITY, SWEDEN · May 12, 2025

Keywords

ClinConnect Summary

This clinical trial is looking at how a combination of dietary fibers and probiotics (beneficial bacteria) can affect uric acid levels in people with hyperuricemia, which is a condition where there is too much uric acid in the blood. Researchers will collect stool samples from participants and study how these ingredients impact the metabolism of uric acid in the samples. The goal is to better understand how these combinations might help manage uric acid levels.

To be eligible for the study, participants need to be between 18 and 80 years old, have a body mass index (BMI) between 18.5 and 35, and have a blood uric acid level above a certain threshold. They must also be willing to avoid any probiotic foods or supplements and certain medications that could affect digestion for a specific time before their stool samples are collected. Participants will not be recruited yet, but once it starts, they can expect to contribute to valuable research that may help others with similar health issues.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. Signed informed consent prior to any study-related procedures
• • 2. Age 18-80 years old
• • 3. BMI range 18.5-35 kg/m2
• • 4. Blood uric acid above 0.36 mmol/L (6 mg/dl)
• • 5. Willing to abstain from regular consumption of probiotic supplements or food products containing probiotic bacteria (including fermented food and beverages), until collection of faecal material
• • 6. Willing to abstain from regular consumption of supplements and medications known to alter gastrointestinal function or inflammatory status during the study, until collection of faecal material
• Exclusion Criteria:
• • 1. Diagnosis of type 1 and/or type 2 diabetes
• • 2. Diagnosed inflammatory bowel disease (IBD)
• • 3. Current diagnosis of psychiatric disease/s or syndromes
• • 4. Current diagnosis of neurodegenerative disease
• • 5. Current pregnancy or breastfeeding
• • 6. History of complicated gastrointestinal surgery
• • 7. Systemic use of antibiotics and/or steroid medication in the last 4 months prior to inclusion
• • 8. Regular use of any non-steroidal anti-inflammatory drug (NSAID) for the last 2 months
• • 9. Consumption of any NSAID within 3 days of sample collection
• • 10. Current (or within the last 4 weeks prior to study start) use of probiotic supplementation
• • 11. Any condition or intake of medication which could substantially interfere with the outcome of the study, as decided by the principal investigator's discretion
• • 12. After being included in the study and until collection of faecal material, starting any medication or treatment that could potentially influence the study participation and/or study analysis