Effect of Topical Bromelain Versus Topical Corticosteroids in the Management of Oral Lichen Planus

Launched by CAIRO UNIVERSITY · May 13, 2025

Keywords

ClinConnect Summary

This clinical trial is investigating the effects of bromelain, a natural enzyme from pineapples, compared to standard steroid treatments for managing oral lichen planus (OLP), a condition that causes painful sores in the mouth. The goal is to see if bromelain can help reduce inflammation and promote healing, potentially providing a safer and more effective treatment option for people suffering from this condition.

To participate in the study, individuals must have OLP symptoms but no other visible oral lesions. They also need to be willing to follow the treatment plan and sign consent forms. However, those with other systemic diseases, who have recently used certain medications, or who are pregnant or breastfeeding will not be eligible. The trial is not yet recruiting participants, but if you or someone you know is interested, it's a good idea to keep an eye on it for future updates.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Patients suffering from symptomatic OLP
• • Patients free from any visible oral lesions other than OLP.
• • Patients who agreed to take the supplied interventions.
• • Patient who will agree to participate in the study.
• • Patients who will accept to sign the informed consent.
• Exclusion Criteria:
• • Patients suffering from any systemic disease.
• • Treatment with any systemic treatment such as systemic steroids, other immunosuppressive drugs or non-steroidal anti-inflammatory drugs at least eight weeks.
• • Treatment with any oral topical medications for at least four weeks prior to the study.
• • Pregnant and lactating mothers.