Study to Investigate the Potential Health Benefits of Grapes Seeds Extract Supplementation in the Management of Elevated Blood Pressure or Stage 1 Hypertension

Launched by LIAQUAT UNIVERSITY OF MEDICAL & HEALTH SCIENCES · May 13, 2025

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ClinConnect Summary

This clinical trial is looking at whether a grape seed extract supplement, called Enovita®, can help people manage elevated blood pressure or Stage 1 hypertension. The study will involve adults aged 30 to 65 who have slightly high blood pressure (like a systolic reading between 120-139 mmHg) and who haven't taken blood pressure medications in the last three months. Over eight weeks, participants will take either the Enovita® supplement or a placebo (a non-active pill) to see how it affects their blood pressure and other health aspects, like mood and stress levels.

If you are interested in participating, you should be within the specified age range and meet the blood pressure criteria. It's important to note that those with more serious hypertension, diabetes, or certain other health conditions won't be eligible to join. Participants will need to attend follow-up visits and provide consent to be part of the study. This trial is not yet recruiting, but it aims to understand better how grape seed extract might be a helpful option for managing blood pressure safely.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Adults aged 30 to 65 years.
• • Diagnosed with Elevated Blood Pressure (systolic 120-129 mmHg and diastolic \<80 mmHg) or Stage 1 Hypertension (systolic 130-139 mmHg or diastolic 80-89 mmHg), according to American Heart Association guidelines.
• • No use of antihypertensive medication in the past 3 months.
• • Willing to comply with study procedures and follow-up visits.
• • Able to provide written informed consent.
• Exclusion Criteria:
• • Stage 2 Hypertension (systolic BP ≥140 mmHg or diastolic BP ≥90 mmHg) at screening.
• • Chronic kidney disease (eGFR \< 60 mL/min/1.73 m²).
• • Diabetes mellitus (HbA1c ≥ 6.5%).
• • History of cardiovascular events (myocardial infarction, stroke) in the past 6 months.
• • Known allergy to grape products.
• • Current use of polyphenol supplements or similar herbal products.
• • Pregnancy or breastfeeding.
• • Participation in another clinical trial within the last 30 days.