The Kidney's Response to Exercise in Heat, and the Impact of Vitamin B3 on This Response

Launched by BETH ISRAEL DEACONESS MEDICAL CENTER · May 14, 2025

Keywords

ClinConnect Summary

This clinical trial, titled "The Kidney's Response to Exercise in Heat, and the Impact of Vitamin B3 on This Response," aims to understand how our kidneys react when we exercise in hot conditions. Researchers want to find out how the body’s chemical responses change with different levels of heat stress and whether taking vitamin B3 can influence these changes. This study will involve healthy volunteers who are physically active and meet specific health criteria.

To participate, volunteers should be between the ages of 18 and 75, be in good health with normal kidney function, and not be smokers or take vitamin B3 supplements regularly. Participants will be asked to engage in exercise under controlled heat conditions, and they will learn more about how their bodies respond to heat and the potential effects of vitamin B3. It’s important to note that those with certain medical conditions or allergies may not be eligible for this study. Overall, this trial seeks to improve our understanding of kidney health during exercise in hot environments.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Healthy volunteer
• • Any race
• • Estimated glomerular filtration rate greater than 90 ml/min/1.73m2
• • Urine albumin/creatinine ratio less than 30mg/g
• • Nonsmoker
• • No regular dietary supplements, particularly vitamin B3
• • Physically active, defined as doing at least 150 minutes of physical activity in an average week
• Exclusion Criteria:
• • Medical condition preventing safe participation in exercise during heat
• • Allergy to Vitamin B3
• • Severe food allergies or dietary restrictions that would preclude eating the planned study diet without major modifications