Accelerated Biological Aging is Associated With Increased Risk of T2DM in the MASLD Population

Launched by NINGBO NO. 1 HOSPITAL · May 21, 2025

Keywords

ClinConnect Summary

This clinical trial is studying how biological aging may affect the risk of developing type 2 diabetes (T2DM) in people with and without a liver condition called metabolic dysfunction-associated steatotic liver disease (MASLD). Researchers will use various methods to assess biological age and analyze its relationship with T2DM risk. Participants will undergo a series of health checks, including abdominal ultrasounds and measurements of factors like body weight and blood sugar levels.

To be eligible for the study, participants should be between 20 and 90 years old, have had certain health data recorded during their annual check-ups, and cannot already have type 2 diabetes or other specific liver conditions. The trial is currently recruiting participants, and those who join can expect regular health assessments that will help researchers understand the connection between aging and diabetes risk. It's an important study aimed at improving our understanding of how age affects health, particularly regarding diabetes and liver health.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. Abdominal ultrasound data available in annual health check-up records
• 2. At least one of the following five metabolic indicators recorded annually:
• • (1) Body mass index (BMI) or waist circumference (2) Blood pressure (3) Serum triglycerides (4) High-density lipoprotein cholesterol (HDL-C) (5) Fasting plasma glucose or glycated hemoglobin (HbA1c)
• Exclusion Criteria:
• • 1. Age \<20 or \>90 years
• • 2. Other causes of hepatic steatosis (e.g., alcoholic liver disease or hepatitis B infection)
• • 3. Type 2 diabetes mellitus at baseline
• • 4. Missing baseline data for any of the following variables: systolic blood pressure, albumin, alkaline phosphatase, blood urea nitrogen, creatinine, glycated hemoglobin (HbA1c), total cholesterol, lymphocyte percentage, white blood cell count, mean corpuscular volume, uric acid, fasting plasma glucose, and red cell distribution width (RDW)