Effect of Subanaesthetic Dose of Ketamine on Depth of Anaesthesia Consistency
Launched by SIR GANGA RAM HOSPITAL · May 15, 2025
Trial Information
Current as of June 26, 2025
Recruiting
Keywords
ClinConnect Summary
This clinical trial is studying the effects of a low dose of ketamine when used alongside propofol during general anesthesia for patients undergoing elective laparoscopic surgery. General anesthesia is a state where patients are made completely unconscious and free from pain during surgery. The trial aims to see if adding ketamine can help make the depth of anesthesia more consistent, which means ensuring that patients stay at the right level of unconsciousness throughout the procedure. Participants will be given either a small dose of ketamine or a placebo (a harmless saline solution) along with propofol, which is the main anesthetic used.
To be eligible for this trial, participants should be between 18 and 75 years old and scheduled for laparoscopic surgery that will last longer than an hour. They should also be in good health, with no serious heart, liver, or kidney problems, and should not have any known allergies to the study medications. Participants can expect to receive the standard anesthetic care, with close monitoring throughout the surgery. This study is not yet recruiting, but it could provide valuable insights into improving anesthesia practices in the future.
Gender
ALL
Eligibility criteria
- Inclusion Criteria:
- • ASA physical status I and II.
- • Patients scheduled for elective laparoscopic surgery with estimated duration greater than 60-minutes.
- Exclusion Criteria:
- • Known uncontrolled cardiovascular disease (e.g., hypertension, systolic and diastolic dysfunction)
- • Liver function abnormality (liver enzymes \>2 times the normal range)
- • Kidney function abnormality (serum creatinine \>1.4 mg/dl)
- • Known psychiatric or neurological disorder
- • Known uncontrolled endocrine disorder (diabetes mellitus, hypothyroidism)
- • Known allergy or hypersensitivity to the study drug
- • Recent intake of sedative medication or anti-psychotic medication
- • Substance abuse
- • Anticipated need for postoperative ventilation
- • Refusal to informed consent
About Sir Ganga Ram Hospital
Sir Ganga Ram Hospital is a premier multi-specialty healthcare institution located in New Delhi, India, renowned for its commitment to delivering high-quality patient care and advancing medical research. Established in 1954, the hospital is equipped with state-of-the-art facilities and a team of highly skilled professionals dedicated to clinical excellence. As a clinical trial sponsor, Sir Ganga Ram Hospital actively engages in innovative research initiatives aimed at improving treatment outcomes and enhancing patient safety. Through its robust ethical framework and adherence to regulatory standards, the hospital fosters a collaborative environment for clinical research, contributing to the global medical community's efforts in developing effective therapies and interventions.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
New Delhi, Delhi, India
Patients applied
Trial Officials
Nitin Sethi, DNB
Study Chair
Sir Ganga Ram Hospital, New Delhi, INDIA
Amitabh Dutta, MD, PGDHR
Study Director
Sir Ganga Ram Hospital, New Delhi, INDIA
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported